Disclosed herein is an invention that refers to hydrochloride metformin complexes with transition metals and group P elements, such as cobalt (II), nickel (II), copper (II), zinc (III), iron (II), bismuth (III) and their preparation method. Additionally, the present invention offers crystalline forms of the metformin-cobalt (II) complex, metformin-nickel complex and metformin-copper complex as well as methods for therapeutic use in patient treatment and their preparation method.

Disclosed herein is an invention that refers to hydrochloride metformin complexes with transition metals and group P elements, such as cobalt (II), nickel (II), copper (II), zinc (III), iron (II), bismuth (III) and their preparation method. Additionally, the present invention offers crystalline forms of the metformin-cobalt (II) complex, metformin-nickel complex and metformin-copper complex as well as methods for therapeutic use in patient treatment and their preparation method.

Provided herein are unsymmetrical bis(azolium) salts, unsymmetrical CCC-NHC metal complexes, and methods of forming the same. The unsymmetrical bis(azolium) salts include a central aryl ring that is substituted with two heterocyclic rings in an ortho, meta, or para fashion. The unsymmetrical CCC-NHC metal complexes include metalated unsymmetrical bis(azolium) salts. The method of forming the unsymmetrical CCC-NHC metal complexes includes reacting a dihalogenated benzene with a first azole to form a mono(azole)benzene, reacting the mono(azole)benzene with a second azole to form an unsymmetrical bis(azole)benzene, alkylating the unsymmetrical bis(azole)benzene to form an unsymmetrical bis(azolium) salt, and metalating the unsymmetrical bis(azolium) salt to form the unsymmetrical CCC-NHC metal complex. Also provided are a bis-ligated CCC-NHC metal complex and an unsymmetrical bimetallic complex.

Provided herein are unsymmetrical bis(azolium) salts, unsymmetrical CCC-NHC metal complexes, and methods of forming the same. The unsymmetrical bis(azolium) salts include a central aryl ring that is substituted with two heterocyclic rings in an ortho, meta, or para fashion. The unsymmetrical CCC-NHC metal complexes include metalated unsymmetrical bis(azolium) salts. The method of forming the unsymmetrical CCC-NHC metal complexes includes reacting a dihalogenated benzene with a first azole to form a mono(azole)benzene, reacting the mono(azole)benzene with a second azole to form an unsymmetrical bis(azole)benzene, alkylating the unsymmetrical bis(azole)benzene to form an unsymmetrical bis(azolium) salt, and metalating the unsymmetrical bis(azolium) salt to form the unsymmetrical CCC-NHC metal complex. Also provided are a bis-ligated CCC-NHC metal complex and an unsymmetrical bimetallic complex.

This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a purified stream with provides an API which has a concentration of the elemental impurity below its permitted daily exposure. The process can be carried in a batch mode where the MOF and feed stream are admixed in a vessel for a given amount of time or continuously by flowing the feed stream through a column or adsorbent bed containing the MOF adsorbent.

This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a purified stream with provides an API which has a concentration of the elemental impurity below its permitted daily exposure. The process can be carried in a batch mode where the MOF and feed stream are admixed in a vessel for a given amount of time or continuously by flowing the feed stream through a column or adsorbent bed containing the MOF adsorbent.

A lactam compound and a salt thereof, represented by general formulae (1) and (2):

##STR00001##

In the formulae, R.sup.1 and R.sup.2 may be the same or different, and each represent a hydrogen atom, a protective group of a carboxyl group or a cation, and X.sup.− is a halogen ion, an organic acid ion, or an inorganic acid ion.

A lactam compound and a salt thereof, represented by general formulae (1) and (2):

##STR00001##

In the formulae, R.sup.1 and R.sup.2 may be the same or different, and each represent a hydrogen atom, a protective group of a carboxyl group or a cation, and X.sup.− is a halogen ion, an organic acid ion, or an inorganic acid ion.

The present invention relates to a metal complex compound which are prepared in the form of a metal nanostructure having various stereo structures and thus can be used as a catalyst or the like having an excellent activity in preparing a polyalkylene carbonate resin and the like, and a metal nanostructure and a catalyst composition comprising the same. The metal complex compound comprises a plurality of linear inorganic coordination polymer chains having a form in which an oxalic acid is coordinated and linked to a transition metal and the plurality of polymer chains are linked to each other via a predetermined neutral ligand.

The present invention relates to a metal complex compound which are prepared in the form of a metal nanostructure having various stereo structures and thus can be used as a catalyst or the like having an excellent activity in preparing a polyalkylene carbonate resin and the like, and a metal nanostructure and a catalyst composition comprising the same. The metal complex compound comprises a plurality of linear inorganic coordination polymer chains having a form in which an oxalic acid is coordinated and linked to a transition metal and the plurality of polymer chains are linked to each other via a predetermined neutral ligand.