The current invention is directed towards compounds of the general formula (I), wherein the integers are defined as follows: R.sup.1 is —(CH.sub.2)nCH(CH.sub.3).sub.2, R.sup.2 is —(CH.sub.2).sub.n+2CH(CH.sub.3).sub.2, G.sup.1 selected from monosaccharides with 4 to 6 carbon atoms, x in the range of from 1.1 to 4, n is a number in the range of from zero to 3. ##STR00001##

The current invention is directed towards compounds of the general formula (I), wherein the integers are defined as follows: R.sup.1 is —(CH.sub.2)nCH(CH.sub.3).sub.2, R.sup.2 is —(CH.sub.2).sub.n+2CH(CH.sub.3).sub.2, G.sup.1 selected from monosaccharides with 4 to 6 carbon atoms, x in the range of from 1.1 to 4, n is a number in the range of from zero to 3. ##STR00001##

This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H derivative.

The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours. The said oligosaccharide-protein conjugates are useful in production of monovalent vaccine or multivalent combination vaccines and as diagnostic tool.

The current invention is directed towards mixtures of compounds, comprising (A) in the range of from 93 to 97% by weight compound of general formula (I) (B) in the range of from 3 to 6.5% by weight compound of general formula (II) (C) in the range of from 0.2 to 0.5% by weight compound of general formula (III) wherein the integers are defined as follows: R.sup.1 is —(CH.sub.2).sub.nCH.sub.3, R.sup.2 is —(CH.sub.2).sub.n+2CH.sub.3, R.sup.3 is —(CH.sub.2).sub.n+1CH(CH.sub.3).sub.2, R.sup.4 is —(CH.sub.2).sub.n−1CH(CH.sub.3).sub.2 G.sup.1 selected from monosaccharides with 4 to 6 carbon atoms, x in the range of from 1.1 to 10, n is a number in the range of from 1 to 4. ##STR00001##

The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.

The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.

A process to produce an aqueous solution of carbohydrates that contains C6-sugar-containing oligomers, C6 sugar monomers, C5-sugar-containing oligomers, C5 sugar monomers, or any combination thereof is presented. The process includes the steps of reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof. A solute is added to the product mixture to cause partitioning of the product mixture into an aqueous layer containing the carbohydrates and a substantially immiscible organic layer containing the lactone.

A process to produce an aqueous solution of carbohydrates that contains C6-sugar-containing oligomers, C6 sugar monomers, C5-sugar-containing oligomers, C5 sugar monomers, or any combination thereof is presented. The process includes the steps of reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof. A solute is added to the product mixture to cause partitioning of the product mixture into an aqueous layer containing the carbohydrates and a substantially immiscible organic layer containing the lactone.

The invention relates to methods and compositions for the production of fucosylated oligosaccharides.