A method of proteolyzing a protein, including immobilizing a protein in at least one pore of a porous body, and contacting the protein immobilized in the pore and a protease immobilized on a solid surface such that the protease selectively accesses a site of the protein and proteolyzes the protein at the site.

The present invention provides to novel prophylactic and therapeutic formulations being effective in the prevention and/or the reduction of allergenic responses to specific allergens. In particular the invention provides compositions comprising deglycosylated allergens which allergens are normally glycosylated in their natural environment. Further this invention further relates to hypoallergenic recombinant deglycosylated derivatives of the major protein allergen from Dermatophagoides pteronyssinus, allergen proDerp1. Even more particularly the invention further provides hypoallergenic recombinant deglycosylated derivatives of proDerp1 of which catalytic cysteine 132 is mutated.

The present invention relates to a method for producing a site-specifically serine ADP-ribosylated protein or peptide being, comprising: (a) subjecting a protein or peptide comprising or consisting of an amino acid sequence comprising two or more serines, wherein at least one serine is phosphorylated and at least one serine is non-phosphorylated, to a serine ADP-ribosylation reaction. The present invention also relates to a site-specifically serine ADP-ribosylated protein or peptide produced by the method of the invention.

The present invention relates to a method for producing a site-specifically serine ADP-ribosylated protein or peptide being, comprising: (a) subjecting a protein or peptide comprising or consisting of an amino acid sequence comprising two or more serines, wherein at least one serine is phosphorylated and at least one serine is non-phosphorylated, to a serine ADP-ribosylation reaction. The present invention also relates to a site-specifically serine ADP-ribosylated protein or peptide produced by the method of the invention.

A keratin hydrolysate including at least 88% by weight of free amino acids relative to the total weight of the amino acids of the hydrolysate, the remainder of the hydrolysate being peptides having a molecular mass of less than or equal to 800 Dalton, the hydrolysate also including L-cystine in a content ranging from 4% to 6%, cysteine in a content of less than or equal to 0.1%, and tyrosine in a content of less than or equal to 0.6% by weight, relative to the total weight of the hydrolysate. Also, a process for preparing the hydrolysate, the oral cosmetic use of the hydrolysate for improving the appearance of the nails and/or of the hair, and a dietary supplement including the hydrolysate and optionally vitamins, zinc and/or L-cystine.

The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.

A cell hydrolysate composition, the composition comprising substantially all protein polypeptides and/or polypeptide fragments derived substantially from all the proteins in a cell from an in vitro cell culture.

A cell hydrolysate composition, the composition comprising substantially all protein polypeptides and/or polypeptide fragments derived substantially from all the proteins in a cell from an in vitro cell culture.

An object of the present invention is to provide a composition for use in improving, maintaining and/or ameliorating an attention function and/or a judgement function. According to the present invention, there is provided a composition for use in improving, maintaining and/or ameliorating an attention function and/or a judgement function, comprising an enzymatic decomposition product of milk protein as an active ingredient. The enzymatic decomposition product of milk protein is preferably an enzymatic decomposition product of whey protein. The enzymatic decomposition product of milk protein preferably comprises a peptide having an amino acid sequence of GTWY (SEQ ID NO: 1) and a peptide having an amino acid sequence of WY.

The present disclosure relates to novel embolization particles and a method for preparing the same.