C07K16/16

HUMAN ANTIBODIES TO BET V 1 AND METHODS OF USE THEREOF

Provided herein are antibodies that bind Fagales allergens, Fagales related allergens, birch pollen, or Bet v 1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments, the antibodies are fully human monoclonal antibodies that bind to Bet v 1. The antibodies are useful for binding Bet v 1 in vivo, thus preventing binding of the allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the Fagales allergens in sensitized individuals.

HUMAN ANTIBODIES TO BET V 1 AND METHODS OF USE THEREOF

Provided herein are antibodies that bind Fagales allergens, Fagales related allergens, birch pollen, or Bet v 1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments, the antibodies are fully human monoclonal antibodies that bind to Bet v 1. The antibodies are useful for binding Bet v 1 in vivo, thus preventing binding of the allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the Fagales allergens in sensitized individuals.

ANTI-CANNABIDIOL ANTIBODY AND USES THEREOF
20210072265 · 2021-03-11 ·

This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.

ANTI-CANNABIDIOL ANTIBODY AND USES THEREOF
20210072265 · 2021-03-11 ·

This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.

Generation of human allergen- and helminth-specific IgE monoclonal antibodies for diagnostic and therapeutic use
10908168 · 2021-02-02 · ·

The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

Generation of human allergen- and helminth-specific IgE monoclonal antibodies for diagnostic and therapeutic use
10908168 · 2021-02-02 · ·

The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

ANTI-GLIADIN ANTIBODIES

The present invention provides anti-gliadin antibodies and antibody fragments, and polypeptides encoding the antibodies or fragment. Also disclosed are methods and Kits for the use of such antibodies, fragments, or polypeptides in detection of gliadin. Further provided are heavy chain and light chain variable sequences and associated sequences of complementarity-determining regions (CDRs).

ANTI-GLIADIN ANTIBODIES

The present invention provides anti-gliadin antibodies and antibody fragments, and polypeptides encoding the antibodies or fragment. Also disclosed are methods and Kits for the use of such antibodies, fragments, or polypeptides in detection of gliadin. Further provided are heavy chain and light chain variable sequences and associated sequences of complementarity-determining regions (CDRs).

Anti-cannabidiol antibody and uses thereof
11860174 · 2024-01-02 · ·

This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.

Anti-cannabidiol antibody and uses thereof
11860174 · 2024-01-02 · ·

This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.