The instant disclosure provides isolated antibodies that specifically bind to TIGIT (e.g., human TIGIT). Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Multi-specific binding proteins that bind to and kill human cancer cells expressing CD33 (Siglec-3) are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of CD33 expressing cancer. The invention relates to multi-specific binding proteins that bind to human cancer cells expressing CD33, and exhibit high potency and maximum lysis of target cells compared to anti-CD33 monoclonal antibodies.

An antibody or antibody fragment that binds to complement protein C7 in isolation or as part of a protein complex and the various uses, for example for the treatment of a disease associated with the dysregulation of complement in a subject.

The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to improved TfR-binding moieties based on shark VNARs capable of crossing the blood brain barrier (BBB) and capable of carrying and releasing cargo specifically targeted to the parenchymal tissue of the brain.

Materials and methods for treating polycystic kidney disease (e.g., autosomal dominant polycystic kidney disease (ADPKD)) are provided herein that include using one or more inhibitors of pregnancy associated plasma protein A (PAPP-A) polypeptide expression or activity.

The invention relates to PD-1 binding agents that block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.

Provided herein are antibodies to DC-SIGN, conjugates of DC-SiGN antibodies, and DC-SiGN antibody fusion proteins and the use of such antibodies, conjugates, and fusion proteins for the treatment of diseases such as cancer.

Methods and devices are provided herein for identifying a cell population comprising an effector cell that exerts an extracellular effect. In one embodiment the method comprises retaining in a microreactor a cell population comprising one or more effector cells, wherein the contents of the microreactor further comprise a readout particle population comprising one or more readout particles, incubating the cell population and the readout particle population within the microreactor, assaying the cell population for the presence of the extracellular effect, wherein the readout particle population or subpopulation thereof provides a direct or indirect readout of the extracellular effect, and determining, based on the results of the assaying step, whether one or more effector cells within the cell population exerts the extracellular effect on the readout particle. If an extracellular effect is measured, the cell population is recovered for further analysis to determine the cell or cells responsible for the effect.

The present disclosure provides human T-cell immune response cDNA 7 (TIRC7) antibodies, having improved TIRC7 binding affinity, and/or activity. The TIRC7 antibodies of the invention are generated by mutation of a parent TIRC7 antibody reports most of the humanized candidates, position 43 was Q (Gln, amide). But in the best humanized VH (cAb1466-VH) mutation of position 43 was Q (Gln, amide) to K (Lys, basic) appears to important for successful affinity/stability over the next best humanized VH.

The present invention is based, in part, on the discovery of anti-LRRC25 compositions (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate inflammatory phenotypes of myeloid cells, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-LRRC25 compositions for therapeutic, diagnostic, prognostic, and screening purposes.