Provided are a hydroxyalkylalkyl cellulose excellent in formability and not causing marked delay in disintegration when added even in a small amount; a solid preparation including the hydroxyalkylalkyl cellulose; and a method for producing the solid preparation. More specifically, provided are a hydroxyalkylalkyl cellulose for tableting having a specific surface area of from 0.5 to 5.0 m.sup.2/g as measured by BET and a solid preparation including the hydroxyalkylalkyl cellulose. Also provided is a method for producing the hydroxyalkylalkyl cellulose for tableting, including the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain an alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first hydroxyalkylalkyl cellulose, grinding the first hydroxyalkylalkyl cellulose, and subjecting the ground first hydroxyalkylalkyl cellulose to hydrolysis in the presence of an acid catalyst or oxidative degradation in the presence of an oxidant to obtain a second hydroxyalkylalkyl cellulose.

The invention related to organic and bioorganic combinatorial chemistry, namely, to new combinatorial libraries of polysaccharide derivatives and supramolecular structures based on them, which, when used without separation into separate components, have high biological activity.

The essence is a combinatorial library and a supramolecular structure based on it from biologically active derivatives of polysaccharides, as well as pharmaceutical compositions based on them with a hemostatic, wound healing, antiviral and immunomodulating action, containing as an active substance an undivided whole combinatorial mixture of substituted glucopyranose polymer derivatives, obtained simultaneous combinatorial modification of a polysaccharide with at least two covalent modifier in the synthesis, a combinatorial mixture with the maximum number of combinations of modified polysaccharide derivatives is formed, and as a biologically active substance, a whole combinatorial mixture of polysaccharide derivatives in the form of a supramolecular structure without separation into individual components is used to obtain a pharmaceutical composition.

The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.

The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.

The invention relates to a method for producing a low-viscosity cellulose ether product, and to the use thereof.

The invention relates to a method for producing a low-viscosity cellulose ether product, and to the use thereof.

The present invention is a method to produce a biodegradable thermally induced shape memory polymer (SMP) based on poly(ε-caprolactone) (PCL) and ethyl cellulose (EC). In this synthesis method, after grafting the PCL on the linear EC, the PCL chains are end-functionalized with furan and maleimide moieties. The cross-linked network is prepared via Diels-Alder (DA) reaction between furanyl and N- maleimidyl PCL chains. The synthesized SMP demonstrates excellent shape memory properties at near body temperature (41° C.). Moreover, the polymer network is recyclable and re-processable, since the DA reaction is thermally reversible. The SMP of the present invention is well suited for numerous applications, especially in medical devices, given their excellent shape memory performance, tunable materials properties, body temperature-based stimulus, biocompatibility, and potential for biodegradation and resorption.

The present invention is a method to produce a biodegradable thermally induced shape memory polymer (SMP) based on poly(ε-caprolactone) (PCL) and ethyl cellulose (EC). In this synthesis method, after grafting the PCL on the linear EC, the PCL chains are end-functionalized with furan and maleimide moieties. The cross-linked network is prepared via Diels-Alder (DA) reaction between furanyl and N- maleimidyl PCL chains. The synthesized SMP demonstrates excellent shape memory properties at near body temperature (41° C.). Moreover, the polymer network is recyclable and re-processable, since the DA reaction is thermally reversible. The SMP of the present invention is well suited for numerous applications, especially in medical devices, given their excellent shape memory performance, tunable materials properties, body temperature-based stimulus, biocompatibility, and potential for biodegradation and resorption.

The present invention provides novel hybrid polymers having unique physical properties. The hybrid polymers comprise a cellulose ether moiety, a linking group moiety, a spacer group moiety, and a lactam moiety. The present invention also provides compositions comprising the hybrid polymers and methods for preparing and using the hybrid polymers. In a first embodiment, the hybrid polymers have the structure:
A-(L.sub.1-S—(B).sub.k).sub.q
wherein A is derived from a cellulose ether moiety comprising a —OH group; L.sub.1 is a linking group moiety selected from the group consisting of urethanes, amides, esters, carbonates, and phosphate esters, or is derived from a moiety selected from the group consisting of anhydrides, cyclic ethers, and aziridines; S is a spacer group moiety, selected from the group consisting of straight- or branched-chain functionalized and unfunctionalized alkyl, cycloalkyl, alkenyl, and aryl groups, wherein any of the above groups may be with or without heteroatoms, or is a direct bond; and B is a lactam moiety; wherein k≥1 and q≥1. In a second embodiment, the hybrid polymers have the structure:
A-(L.sub.2-S—B).sub.y
wherein A is derived from a cellulose ether moiety comprising a —OH group; L.sub.2 is an ether linking group moiety; S is a spacer group moiety, selected from the group consisting of straight- or branched-chain functionalized and unfunctionalized alkyl, cycloalkyl, alkenyl, and aryl groups, wherein any of the above groups may be with or without heteroatoms, or is a direct bond; and B is a lactam moiety; wherein y≥1; with the proviso that when the cellulose ether moiety is hydroxyethyl cellulose, -(L.sub.2-S—B).sub.y is not derived from 1-(hydroxymethyl)-2-pyrrolidinone.

The present invention relates a composition capable of enhancing cleaning properties of a soil during cleaning by treating an object. The composition is a composition containing a modified hydroxyalkyl cellulose and at least one selected from an anionic surfactant and a nonionic surfactant, the modified hydroxyalkyl cellulose being one in which a cationic group and a hydrophobic group represented by the formula (1) are bound to a group resulting from eliminating a hydrogen atom from a hydroxy group of a hydroxyalkyl cellulose.
*—Z—R.sup.1  (1)
wherein, Z represents a single bond or a hydrocarbon group having an oxygen atom; R.sup.1 represents a hydrocarbon group having 2 or more carbon atoms; and * represents a binding position to a group resulting from eliminating a hydrogen atom from a hydroxy group of a hydroxyalkyl cellulose.