A compound includes a polymer associated with a biological agent. The polymer has a first (meth)acryl monomeric unit with a cationic functional group R1 and a second (meth)acryl monomeric unit with a neutral hydrophilic functional group R2. The cationic functional group R1 is chosen from amino groups and alkylamino groups, and the neutral functional group R2 is chosen from polyethylene glycol (PEG), hydroxyl (OH), phosphorylcholine (PC), and mixtures and combinations thereof.

An aqueous coating composition comprising (a) from 12.5% to 87% by weight based on the weight of the aqueous coating composition, of a film-forming polymer; (b) from 9.5% to 85% by weight based on the weight of the film-forming polymer, of a specific oligomer; and (c) from 2.5% to 50% by weight based on the weight of the film-forming polymer, of beads with a mean particle size of from 5.0 to 10.5 μm; and a process for preparing the aqueous coating composition.

An aqueous coating composition comprising (a) from 12.5% to 87% by weight based on the weight of the aqueous coating composition, of a film-forming polymer; (b) from 9.5% to 85% by weight based on the weight of the film-forming polymer, of a specific oligomer; and (c) from 2.5% to 50% by weight based on the weight of the film-forming polymer, of beads with a mean particle size of from 5.0 to 10.5 μm; and a process for preparing the aqueous coating composition.

The present invention provides amphiphilic comb polymer compositions of phosphorus acid group containing backbone polymers of methacrylic anhydride having hydrophobic alkyl, aryl, cycloalkyl or polyolefin ester or amide side chain groups formed on the backbone polymers and comprising from 75 to 100 wt. %, based on the total weight of monomers used to make the backbone polymer, of methacrylic acid polymerized units, wherein in the backbone polymer from 20 to less than 70 wt. %, preferably from 50 to 67 wt. % of the methacrylic acid polymerized units comprise methacrylic anhydride groups as determined by titration of the backbone polymer. As polymeric additives, the polymers can compatibilize polyolefins and polar polymers like polyesters.

The present invention provides amphiphilic comb polymer compositions of phosphorus acid group containing backbone polymers of methacrylic anhydride having hydrophobic alkyl, aryl, cycloalkyl or polyolefin ester or amide side chain groups formed on the backbone polymers and comprising from 75 to 100 wt. %, based on the total weight of monomers used to make the backbone polymer, of methacrylic acid polymerized units, wherein in the backbone polymer from 20 to less than 70 wt. %, preferably from 50 to 67 wt. % of the methacrylic acid polymerized units comprise methacrylic anhydride groups as determined by titration of the backbone polymer. As polymeric additives, the polymers can compatibilize polyolefins and polar polymers like polyesters.

Provided are a method for easily and quickly producing a patterned thin film having a high refractive index and a high transparency, and a highly refractive thin film produced by the method. The method comprises a first step: a step of forming, on a substrate, a coating using a sol containing a metal oxide modified with a phosphorus compound represented by the following formula (1): ##STR00001##
(wherein R.sup.1 is a hydrogen atom, an alkyl group, an alkynyl group, an alkenyl group, an aryl group, an aliphatic heterocyclic group, or an aromatic heterocyclic group; R.sup.2 is a divalent organic residue; and n is 1 or 2); a second step: a step of curing the coating on the substrate obtained in the first step by light irradiation; and a third step: a step of further adding energy to the cured film obtained in the second step by heating and/or light irradiation.

Provided are a method for easily and quickly producing a patterned thin film having a high refractive index and a high transparency, and a highly refractive thin film produced by the method. The method comprises a first step: a step of forming, on a substrate, a coating using a sol containing a metal oxide modified with a phosphorus compound represented by the following formula (1): ##STR00001##
(wherein R.sup.1 is a hydrogen atom, an alkyl group, an alkynyl group, an alkenyl group, an aryl group, an aliphatic heterocyclic group, or an aromatic heterocyclic group; R.sup.2 is a divalent organic residue; and n is 1 or 2); a second step: a step of curing the coating on the substrate obtained in the first step by light irradiation; and a third step: a step of further adding energy to the cured film obtained in the second step by heating and/or light irradiation.

The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N′-methylenebisacrylamide (BIS) crosslinker.

The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N′-methylenebisacrylamide (BIS) crosslinker.

The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized with a N,N′-methylenebisacrylamide (BIS) crosslinker.