According to one aspect of the present invention, an organic fluorine compound is represented by a general formula
(R-π-E-CH.sub.2).sub.2-A  (1A)
(where A is a divalent perfluoropolyether group, π is an arylene group or a single bond, R is an alkenyl group or an alkynyl group, and E is an ether bond or an ester bond or a group that is represented by a chemical formula
—O—CH.sub.2CH(OH)CH.sub.2O—
two groups each of which is represented by a general formula
R-π-E-CH.sub.2—
may be the same or different, and at least one n among two π is an arylene group).

According to one aspect of the present invention, an organic fluorine compound is represented by a general formula
(R-π-E-CH.sub.2).sub.2-A  (1A)
(where A is a divalent perfluoropolyether group, π is an arylene group or a single bond, R is an alkenyl group or an alkynyl group, and E is an ether bond or an ester bond or a group that is represented by a chemical formula
—O—CH.sub.2CH(OH)CH.sub.2O—
two groups each of which is represented by a general formula
R-π-E-CH.sub.2—
may be the same or different, and at least one n among two π is an arylene group).

Polymers and nanoparticle formulations for systemic nucleic acid delivery, including mRNA, are disclosed. A bioassay for simultaneously measuring nanoparticle cell uptake and endosomal disruption also is disclosed.

The present invention is to provide a cell culture substrate including a block polymer including a segment having a lower critical solution temperature and a hydrophobic segment, the cell culture substrate further including an adhesive matrix, in which the adhesive matrix is an extracellular matrix and/or an adhesive synthetic matrix. Furthermore, the invention is to provide a cell culture substrate in which the extracellular matrix is at least one selected from laminin, fibronectin, vitronectin, cadherin, and fragments thereof, and/or the adhesive synthetic matrix is poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl) ammonium hydroxide] or an oligopeptide-carrying polymer.

An aspect of the present invention is a resin composition containing a modified polyphenylene ether compound of which a terminal is modified with a substituent having a carbon-carbon unsaturated double bond and an inorganic filler, in which the inorganic filler contains silica in which a ratio of a number of Si atoms contained in silanol groups to a total number of Si atoms is 3% or less.

A resin composition is provided containing a polymer having a structural unit represented by the following Formula (1) in the molecule, and an inorganic filler, in which the inorganic filler contains silica in which a ratio of a number of Si atoms contained in silanol groups to a total number of Si atoms is 3% or less.

##STR00001##

In Formula (1), Z represents an arylene group, R.sub.1 to R.sub.3 each independently represent a hydrogen atom or an alkyl group, and R.sub.4 to R.sub.6 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.

An aspect of the present invention is a resin composition containing a first styrene-based block copolymer having a hardness of 20 to 70, a polyphenylene ether compound having at least one of a group represented by the following Formula (1) and a group represented by the following Formula (2) in a molecule, and a curing agent.

##STR00001##

In Formula (1), p represents 0 to 10, Z represents an arylene group, and R.sub.1 to R.sub.3 each independently represent a hydrogen atom or an alkyl group.

##STR00002##

In Formula (2), R.sub.4 represents a hydrogen atom or an alkyl group.

An aspect of the present invention is a resin composition containing a first styrene-based block copolymer having a hardness of 20 to 70, a polyphenylene ether compound having at least one of a group represented by the following Formula (1) and a group represented by the following Formula (2) in a molecule, and a curing agent.

##STR00001##

In Formula (1), p represents 0 to 10, Z represents an arylene group, and R.sub.1 to R.sub.3 each independently represent a hydrogen atom or an alkyl group.

##STR00002##

In Formula (2), R.sub.4 represents a hydrogen atom or an alkyl group.

Provided is an optical article having a substrate, a primer layer generated by curing a polymerizable composition for forming the primer layer, and a photochromic layer generated by curing a (meth)acrylate-based polymerizable composition containing a photochromic compound in this order, in which the polymerizable composition for forming the primer layer contains a component A: polyisocyanate and a component B: hydroxy group-containing (meth)acrylate.

A drilling fluid composition comprising a base fluid, and a drag reducing agent including an ultra-high molecular weight branched block copolymer having the following structure,

##STR00001##

where monomer A is an anionic monomer, monomer B is a hydrophilic monomer, monomer C is an anionic monomer, monomer D is a crosslinker-divinyl monomer, and -SSCZ ground being a terminal RAFT agent.