The present application relates to an amphiphilic polymer and a method for producing the same. The present application also relates to micelles comprising the amphiphilic polymer and a method for producing the same. The amphiphilic polymer of the present application can have excellent dispersion properties while effectively encapsulating the drug.

Aspects generally relate to a temperature responsive polymer, more specifically to a polymer exhibiting an upper critical solution temperature (UCST) in an aqueous solution. In one aspect, a monomer compound includes one or more amide or thioamide groups; one or more ureido or thioureido groups; and one or more ethylenically unsaturated groups. In one aspect, a polymer, such as a homopolymer or a copolymer, is produced by polymerization of the monomer compound. The copolymer is produced by polymerization of the monomer compound and a comonomer, such as a hydrophobic comonomer, a hydrophilic comonomer, a pH responsive comonomer, a light responsive comonomer, and combinations thereof. The polymer exhibits a UCST from about 1° C. to about 100° C. in an aqueous solution at 1 atm.

Disclosed are reversibly-expandable polymer-integrated crystals (PIX) materials, devices, and methods for controllably encapsulating and releasing molecular cargo. The disclosed PIX materials are engineered crystalline materials with large pores that can entrap macromolecules, such as proteins and nanoparticles. The material expands and contracts reversibly, allowing controlled encapsulation and release of guest/cargo molecules.

The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I):

##STR00001##

or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

The present invention relates to the preparation of polymers that are of use in particular as a rheology agent, and are suitable for use in very concentrated saline media, which comprises a step of micellar radical polymerization in which are brought into contact, in an aqueous medium: —hydrophilic monomers; —hydrophobic monomers in the form of a micellar solution, containing micelles comprising these hydrophobic monomers; —a radical polymerization initiator; and —preferably an agent for controlling radical polymerization, wherein said micelles comprise at least one surfactant of amphoteric nature. The polymers obtained according to the invention are in particular of use for enhanced oil recovery.

The invention provides novel polymer-protein conjugates and molecular assemblies for controlled intracellular delivery of proteins, and compositions and methods of preparation and use thereof.

The present invention relates to the use of sequential copolymers (P), comprising at least one chain (C) capable of being obtained by micellar polymerization, for keeping solid particles (p) in suspension in a fluid (F) where said chain (C) is soluble.

A composition for treating a formation includes a surfactant including an amphiphilic block copolymer having a first block and a second block and an acid. The amphiphilic block copolymer is a reaction product of a first monomer and a second monomer via a reversible addition-fragmentation chain transfer polymerization (RAFT) in a two-step reaction using a chain transfer agent (CTA) and a radical initiator. The surfactant favors adsorption onto a surface of the formation such that a temporary barrier is formed, thereby attenuating a reaction rate between the acid and the formation.

The present invention relates to a homopolymer, copolymer, block copolymer, and statistical copolymer comprising plural polyol monomeric units. The polyol monomeric units being acrylated and acylated or acetalized. The acrylated and acylated or acetalized polyol monomeric units have an average degree of acrylation which is 1 or more, but less than the number of the hydroxyl groups of the polyol and have an average degree of acylation or acetalization which is 1 or more, but less than the number of the hydroxyl groups of the polyol. The present invention also relates to a method of making the homopolymers, copolymers, block copolymers, and statistical copolymers, and using them in various applications, such as asphalt rubber modifiers, adhesives, or an additive in a fracking fluid for oil fracking.