[Object]

To provide a derivative of a short chain fatty acid that can exhibit physiological functions inherent in the short chain fatty acid.

[Solution]

Provided is a block or graft copolymer including a hydrophobic segment of a repeat unit containing a short chain fatty acid ester that is hydrolyzable by esterase in vivo and a hydrophilic segment including a poly(ethylene glycol) chain. These copolymers are effective in the treatment or therapeutic treatment of various diseases or disorders, including cancer.

This invention relates to a method for preparing a structured water-soluble polymer having a weight average molecular weight greater than 1 million Daltons and a Huggins Coefficient K.sub.H greater than 0.4, the method comprising the following successive steps: a) Preparing a polymer, in the form of a gel, by free-radical polymerization in aqueous solution at an initiation temperature between −20° C. and +50° C. of at least one water-soluble monounsaturated ethylenic monomer, the total weight concentration of monomer(s) in relation to the polymerization charge being between 10 and 60%; b) Granulating the resulting polymer gel; c) Drying the polymer gel to obtain a polymer in powder form; d) Grinding and sifting the powder; at least 10% by weight of water-soluble polymer, based on the total weight of the water-soluble monounsaturated ethylenic monomer or monounsaturated ethylenic monomers used in step a), being added during the polymerization step a) and optionally during the granulation step b), the water-soluble polymer being structured and added as a water-in-oil inverse emulsion or dispersion in oil.

A pressure-sensitive adhesive composition includes a block copolymer containing a polymer block (A) and a (meth)acrylic polymer block (B), wherein the polymer block (A) contains either or both of a maleimide compound and an amide group-containing vinyl compound as a constitutional monomer thereof and has a glass transition temperature of 100° C. or higher, and the (meth)acrylic polymer block (B) contains at least one selected from compounds represented by general formula (1) as a major constitutional monomer thereof and has a glass transition temperature of 10° C. or below.
CH.sub.2═CR.sup.1—C(═O)O(R.sup.2O).sub.n—R.sup.3  (1)
(wherein, R.sup.1 represents hydrogen or a methyl group; R.sup.2 represents a linear or branched C.sub.2-6 alkylene group; R.sup.3 represents hydrogen, a C.sub.1-20 alkyl group, or a C.sub.6-20 aryl group; and n represents 0 or an integer from 1 to 100.)

Here are described polymers comprising monomeric units from vinylimidazole derivatives and their use in electrode materials and/or electrolyte compositions, as well as their methods of preparation. Also described are electrode materials, electrodes, and electrochemical cells comprising the polymers and their use.

The present disclosure relates to an ion gel having superior ion conductivity and mechanical strength, a polymer electrolyte including the same, and a manufacturing method thereof. The method of manufacturing the ion gel is capable of simply and effectively manufacturing a polymer matrix through a one-pot reaction, thus exhibiting simple processing steps to thereby manifest excellent processing efficiency and generate economic benefits. Moreover, the polymer electrolyte including the ion gel can exhibit superior ion conductivity and mechanical strength despite the low glass transition temperature (Tg) of the monomer contained in the polymer matrix.

A compound includes a polymer associated with a biological agent. The polymer has a first (meth)acryl monomeric unit with a cationic functional group R1 and a second (meth)acryl monomeric unit with a neutral hydrophilic functional group R2. The cationic functional group R1 is chosen from amino groups and alkylamino groups, and the neutral functional group R2 is chosen from polyethylene glycol (PEG), hydroxyl (OH), phosphorylcholine (PC), and mixtures and combinations thereof.

A curable composition including a silicone copolymer, a fluoropolyether group-containing compound, and a matrix-forming composition, wherein the silicone copolymer has two or more crosslinkable groups; and the crosslinkable group is a group containing a carbon-carbon double bond, a carbon-carbon triple bond, a cyclic ether group, a hydroxyl group, a thiol group, an amino group, an azide group, a nitrogen-containing heterocyclic group, an isocyanate group, a halogen atom, a phosphoric acid-containing group, or a silane coupling group, or a precursor group thereof. Also disclosed is a film formed from the curable composition, and an article including a substrate and a layer on a surface of the substrate formed from the curable composition.

The present application relates to a multiblock copolymer comprising at least one PA block, at least one PB block, and at least one PC block. PC block is positioned between PA block and PB block, where PC block is a rubber block, and where PA represents a polymer block comprising one or more units of monomer A, PB represents a polymer block comprising one or more units of monomer B, and PC represents a polymer block comprising one or more units of monomer C, with monomers A and B being the same or different.

Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.