Chemical delivery systems, device and methods are provided. A chemical delivery system may include a vessel and a chip. The vessel may include a groove configured to hold a solution. The groove includes an open surface, the open surface having a first surface area. The solution includes a target material. The chip includes a first side, a second side opposing the first side, and a bottom side. The chip includes one or more chambers configured to hold one or more chemicals, the one or more chambers including a bottom surface having a second surface area. The second surface area is greater than the first surface area. When one of the one or more chambers is positioned over the groove, the respective chemical in the chamber moves into the solution in the groove. The system increases the ease, stability, and reliability of a chemical delivery process.

Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

Compositions are provided that contain biologically active components of amniotic fluid including growth factors and other proteins, carbohydrates, lipids, and metabolites. The compositions containing biologically active components of amniotic fluid can be useful for a range of therapeutic treatments including joint and soft tissue repair, regulation of skin condition, and for use in organ preservation, such as for use in organ transplant procedures. Advantages of the compositions include that they can be reproducibly produced, without the inherent variability of amniotic fluid from individual donors, and that they are free of fetal waste.

Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.

The present invention relates to a device for transport and preservation of an ex vivo biological sample and corresponding method. The device (1) comprises a chamber (2) for containing the biological sample (100), delimitated by walls (4) made of a thermal insulating material. The device, furthermore, incorporates cooling means (6) that keep the temperature inside the chamber (2) below the temperature outside the device (1). Finally, an ultrasound system suitable for generating and applying ultrasound on the biological sample (100) is provided. The invention also proposes a method for transport and preservation which combines applying cooling and ultrasound to reduce cell damage in the biological sample.

The present invention relates to a platelet protection solution (PPS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.

Provided are 1) a hollow fiber cryopreservation instrument having a long support on which a hollow fiber is placed, wherein the support is formed of a low-temperature-resistant material, and 2) a cell cryopreservation method having a process of placing a hollow fiber on the support of the hollow fiber cryopreservation instrument, and a process of cryopreserving cells in a state in which the hollow fiber is placed on the support.

A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.

An apparatus, that relates to the field of in vitro fertilization, is provided for the combined incubation and vitrification of a biological material. The apparatus can be configured to allow for automatic incubation and vitrification of a viable biological material. Thereby predetermined protocols for handling the biological material can be performed precisely and accurately thus avoiding errors and deviations from the intended protocol, as caused by manual human intervention.

The present invention provides pathogen-inactivated red blood cell compositions.