The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.

A copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, such as a catheter balloon, with improved bursting strength, in which said copolymer has the following characteristics: number-average molecular mass of the PE blocks greater than 500 g/mol, and number-average molecular mass of the PA blocks greater than 10 000 g/mol.

There is provided a tire comprising a tire frame that is formed of a resin material and has a circular form, wherein the resin material comprises a thermoplastic elastomer having a structure including a hard segment (HS) and a soft segment (SS), which repeat alternately, in which a number of repeating units in one molecular chain is from 2 to 10, each of the repeating units being a pair of the hard segment (HS) and the soft segment (SS), the thermoplastic elastomer having a number average molecular weight of from 45,000 to 160,000.

There is provided a tire comprising a tire frame that is formed of a resin material and has a circular form, wherein the resin material comprises a thermoplastic elastomer having a structure including a hard segment (HS) and a soft segment (SS), which repeat alternately, in which a number of repeating units in one molecular chain is from 2 to 10, each of the repeating units being a pair of the hard segment (HS) and the soft segment (SS), the thermoplastic elastomer having a number average molecular weight of from 45,000 to 160,000.

A circular tire frame includes a resinous material including a polyamide-based thermoplastic elastomer and a caprolactam.

A flexible polyamide including a unit formed from an aliphatic dicarboxylic acid (A1) having 18 or more carbon atoms and/or a unit formed from an aliphatic diamine (B1) having 18 or more carbon atoms, wherein the polyamide has a total content of 10 to 90% by mass of the unit formed from (A1) and the unit formed from (B1) and has a melting point of 240° C. or higher.

There is provided a tire including a tire frame that is formed of a resin material and has a circular form, wherein the resin material includes a thermoplastic elastomer having a hard segment (HS) and a soft segment (SS), in which only one unit of the soft segment (SS) is included in a single molecular chain, and both terminals of the single molecular chain are formed by the hard segment (HS), the thermoplastic elastomer having a number average molecular weight of from 12,000 to 24,000.

The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.

The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.

The present invention is directed to polyamides that are crosslinkable in the presence of water having desirable properties including long open time, good adhesion and cold flexibility. Notably, the polyamides of the present invention are suitable for structural and semi-structural bonding applications utilizing a hot melt process, roll coater or bead extrusion process.