The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

The present invention relates to a film-forming dispersion comprising a functionalized polyamide and water.

The present invention relates to a film-forming dispersion comprising a functionalized polyamide and water.

The invention pertains to a polymer composition possessing improved resistance towards degradation and discolouring phenomena induced by UV radiation, said composition comprising at least one aromatic sulfone polymer; at least one organic UV absorber and at least one basic compound selected from the group consisting of (i) basic oxides and hydroxides of divalent metals and (ii) salts of a weak acid, and to methods for its manufacture and to shaped articles obtained therefrom.

The invention pertains to a polymer composition possessing improved resistance towards degradation and discolouring phenomena induced by UV radiation, said composition comprising at least one aromatic sulfone polymer; at least one organic UV absorber and at least one basic compound selected from the group consisting of (i) basic oxides and hydroxides of divalent metals and (ii) salts of a weak acid, and to methods for its manufacture and to shaped articles obtained therefrom.

The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as:

##STR00001##

wherein
R.sup.I1 is Z or

##STR00002##

wherein
R.sup.I2 is H, SO.sub.3H, or

##STR00003## ##STR00004##

wherein
R.sup.I3 is H or

##STR00005##

wherein
R.sup.I4 is H or

##STR00006##

wherein
R.sup.I5 and R.sup.I6 are independently H or

##STR00007##

wherein
R.sup.I7 is H or

##STR00008##

and compounds of formula (II) are defined as:

##STR00009##

wherein
R.sup.II1 is Z or

##STR00010##

wherein
R.sup.II2 is Z or

##STR00011##

wherein Z is —N(R.sup.a)-A-B—CH.sub.2—(CH.sub.2).sub.q—SH, wherein
R.sup.a is H, C, Ca alkyl, C.sub.1-C.sub.4-alkoxy, CH.sub.2C.sub.6H.sub.5, CH.sub.2CH.sub.2C.sub.6H.sub.5, OCH.sub.2C.sub.6H.sub.5, or OCH.sub.2CH.sub.2C.sub.6H.sub.5;
A is C.sub.1-C.sub.7-alkylene, C.sub.1-C.sub.7-alkoxy, C.sub.1-C.sub.4-alkyl-(OCH.sub.2CH.sub.2).sub.pO—C.sub.1-C.sub.4-alkyl, or
C.sub.1-C.sub.7-alkoxy-R.sup.b, wherein R.sup.b is an optionally substituted aryl or an optionally substituted heteroaryl, and wherein p is 0 to 6, preferably p is 1, 2 or 3, and further preferably p is 1;
B is NHC(O), S or CH.sub.2;
q is 0 to 6, preferably q is 1, 2, 3 or 4, and further preferably q is 1 or 2.

The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as:

##STR00001##

wherein
R.sup.I1 is Z or

##STR00002##

wherein
R.sup.I2 is H, SO.sub.3H, or

##STR00003## ##STR00004##

wherein
R.sup.I3 is H or

##STR00005##

wherein
R.sup.I4 is H or

##STR00006##

wherein
R.sup.I5 and R.sup.I6 are independently H or

##STR00007##

wherein
R.sup.I7 is H or

##STR00008##

and compounds of formula (II) are defined as:

##STR00009##

wherein
R.sup.II1 is Z or

##STR00010##

wherein
R.sup.II2 is Z or

##STR00011##

wherein Z is —N(R.sup.a)-A-B—CH.sub.2—(CH.sub.2).sub.q—SH, wherein
R.sup.a is H, C, Ca alkyl, C.sub.1-C.sub.4-alkoxy, CH.sub.2C.sub.6H.sub.5, CH.sub.2CH.sub.2C.sub.6H.sub.5, OCH.sub.2C.sub.6H.sub.5, or OCH.sub.2CH.sub.2C.sub.6H.sub.5;
A is C.sub.1-C.sub.7-alkylene, C.sub.1-C.sub.7-alkoxy, C.sub.1-C.sub.4-alkyl-(OCH.sub.2CH.sub.2).sub.pO—C.sub.1-C.sub.4-alkyl, or
C.sub.1-C.sub.7-alkoxy-R.sup.b, wherein R.sup.b is an optionally substituted aryl or an optionally substituted heteroaryl, and wherein p is 0 to 6, preferably p is 1, 2 or 3, and further preferably p is 1;
B is NHC(O), S or CH.sub.2;
q is 0 to 6, preferably q is 1, 2, 3 or 4, and further preferably q is 1 or 2.

It is an object of the present invention is to provide a sheet containing ultrafine cellulose fibers, which is excellent in transparency and water resistance. The present invention relates to a sheet including cellulose fibers having a fiber width of 1000 nm or less, and polyamine polyamide epihalohydrin, wherein the haze of the sheet is 6% or less.

It is an object of the present invention is to provide a sheet containing ultrafine cellulose fibers, which is excellent in transparency and water resistance. The present invention relates to a sheet including cellulose fibers having a fiber width of 1000 nm or less, and polyamine polyamide epihalohydrin, wherein the haze of the sheet is 6% or less.