Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups E.sub.c form a highly symmetric octavalent central structure CORE.sub.0 together, L.sub.c connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n.sub.1-n.sub.8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k1), and said PEG chain and F can be directly connected (g=0) or connected with a divalent linking group L.sub.0 connected with a terminal branched group G (g=1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity. The near-center symmetric structure of the derivative allows more precise control over the molecular weight during large-scale production, thereby facilitating acquisition of a product having a narrower molecular weight distribution. A bio-related substance modified thereby has a more uniform and controllable performance.

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The present disclosure relates to a hybrid nanoparticle comprising: (a) a metallic core or a metal oxide core, and (b) at least one dendron attached to the surface of the metallic core or metal oxide core, wherein the at least one dendron is derived from a compound complying with formula (I) or (II), which is described herein, as well as films containing such hybrid nanoparticles. Also described are compounds complying with formula (I) or (II) and their use in forming the hybrid nanoparticles of the present disclosure.

Dendrimeric metallacrowns may include a monomeric metallacrown complex or a dimeric metallacrown complex. In an example, the dendrimeric metallacrown includes the monomeric metallacrown complex and a dendron. In this example, the monomeric metallacrown complex includes a central ion, and a metallomacrocycle attached to the central ion. The central ion is selected from the group consisting of a lanthanide ion, a d-block transition metal ion or rare earth metal ion, and an s-block alkali or alkaline earth metal. The metallomacrocycle includes a repeating sub-unit consisting of a metal ion and a ring ligand selected from the group consisting of a hydroxamic acid derivative and an oxime derivative. The dendron is respectively attached to each of the ring ligands of the metallomacrocycle.

According to the present disclosure, a method of forming a pattern may include forming guide patterns on a substrate, wherein a trench is provided between the guide patterns, forming an organic-inorganic pattern including organic supramolecular structures in the trench, and annealing the organic-inorganic pattern, thereby aligning the dendrimer structures in parallel with one direction.

Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

The present invention relates to a curable antistatic primer composition, comprising: (d) at least one polyalkylene oxide polymer; (e) at least a Lithium salt; (f) at least an amorphizer selected from at least a dendritic polymer. The present invention also relates to an optical article having at least one surface comprising an antistatic primer coating obtained by depositing on a substrate and curing said composition, and its production method.

Conjugates of SN-38 that provide optimal drug release rates and minimize the formation of the corresponding glucuronate are described. The conjugates release SN-38 from a polyethylene glycol through a -elimination mechanism.

Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

Conjugates of SN-38 that provide optimal drug release rates and minimize the formation of the corresponding glucuronate are described. The conjugates release SN-38 from a polyethylene glycol through a -elimination mechanism.

The invention relates to a multilayer structure comprising at least one layer of supramolecular material and one layer of rigid material, to a method for producing such a structure by casting a composition comprising a precursor of the supramolecular material, and to the uses of the structures produced, especially for applications where a dampening of impacts, vibrations and/or sound waves is desired, for example for producing locomotion vehicles such as automotive, rail, nautical, aeronautical or aerospace vehicles, or for the construction industry.