The invention relates to polymer-interaction molecule (e.g., antibodies) conjugates and uses of such conjugates for delivery of interaction molecules to cells. The invention also relates uses polymer-interaction molecule (e.g., antibodies) conjugates for eliciting cellular responses (e.g., induction of cell proliferation).

The present invention provides rotaxanes comprising a macrocycle surrounding an ion comprising a blocking group capable of trapping the macrocycle. Also provided are methods of making such rotaxanes and a method of removing the blocking group from the rotaxane, thereby allowing the ion to escape the macrocycle. The ions have been found to have anticancer, antibacterial and/or antiviral properties. Accordingly, the rotaxanes of the invention may be useful in the treatment of cancer, bacterial and/or viral diseases.

Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.

An object of the present invention is to provide a novel rotaxane and a production method of the same. The present invention provides a rotaxane polyurea having a cyclic molecule and a polyurea chain piercing through the cyclic molecule.

The present disclosure provides a rotaxane polymer binder containing a polymer based on a rotaxane structure. The polymer binder may further contain a polymer cross-linked with a polar polymer. The polar polymer may be a polymer containing the element F, O or N in a functional group and having high polarity. In addition, the present disclosure provides an electrode containing the rotaxane polymer binder as a binder for a lithium secondary battery, and a secondary battery containing the electrode.

Disclosed herein are embodiments of nanohoop compounds, methods of making, and methods of using the same. The nanohoop compounds disclosed herein have discrete ring system(s) that comprise a unique meta-substituted motif that affords a strained cavity in which myriad reaction chemistries can take place. The unique structures and properties of the nanohoop compounds disclosed herein also lend to their use in a variety of biological applications, and as interlocked structures in molecular machines.

The present invention relates to a photopolymer composition comprising: a polymer matrix or a precursor thereof including a reaction product of a polyol including a polyrotaxane compound and a compound containing at least one isocyanate group; a photoreactive monomer; and a photoinitiator. The present invention also relates to a hologram recording medium produced from the photopolymer composition, an optical element comprising the hologram recording medium, and a holographic recording method using the photopolymer composition.

A photochromic polyrotaxane compound which comprises an axial molecule and a plurality of cyclic molecules clathrating the axial molecule, wherein at least one side chain containing a photochromic moiety is bonded to at least one of the cyclic molecules, and a curable composition comprising the photochromic polyrotaxane compound and a polymerizable compound.

Luminescent reporter compounds that are rotaxanes having the structure ##STR00001##
where B—Z—C is a reporter molecule based on a squaraine type molecule, or similar reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.

The present invention provides a production method for pseudo-polyrotaxane or polyrotaxane in which the degree of ring-shaped molecules included on straight-chain molecules, that is, the inclusion rate, has been controlled to be low and stable. The present invention provides a production method for polyrotaxane formed by blocking groups being positioned at both ends of a pseudo-polyrotaxane so ring-shaped molecules are not released, said pseudo-polyrotaxane being formed by ring-shaped molecules skewered through openings thereof by straight-chain molecules, wherein polyrotaxane is obtained by means of said method having: (A) a step for preparing straight-chain molecules which have acidic or basic functional groups on both ends; (B) a step for forming pseudo-polyrotaxane by means of having a step for mixing the straight-chain molecules, the ring-shaped molecules, and a first basic group or an acid addition salt (the acid addition salt is used when the straight-chain molecules have the acidic functional groups; a base addition salt is used when the straight-chain molecules have the basic functional groups); and (C) a step for providing blocking groups on both ends of the straight-chain molecules by means of having a step for mixing the obtained pseudo-polyrotaxane and a blocking group precursor.