The present invention relates to a supramolecular biodegradable polymer comprising a quadruple hydrogen bonding unit (abbreviated herein as 4H-unit), a biodegradable backbone and hard blocks and a process for preparing such a supramolecular biodegradable polymer. The supramolecular polymer is specifically suitable for biodegradable articles such as biomedical implants that need high strength and/or elasticity, e.g. medical implants in the cardio-vascular field.

Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.

A tissue adhesive membrane and a preparation method thereof are provided. The tissue adhesive membrane includes a supramolecular polymer and an enhancer; the supramolecular polymer is prepared by copolymerization of lipoic acid and a biocompatible stabilizer; and the enhancer includes at least one selected from the group consisting of a cationic compound, a cationic polymer, and a metal particle. The tissue adhesive membrane of the present invention can achieve rapid adhesion, seal wounds continuously and effectively, and maintain long-lasting mechanical strength. The components of the tissue adhesive membrane come from natural components of animals and plants, have good biocompatibility, and possess the functions of antibacterial and inhibiting inflammation. The tissue adhesive membrane of the present invention is a hydrophobic adhesive membrane where hydrogen bonding and high surface energy can provide strong adhesion energy and no adverse active groups that may cause irritation or discomfort are contained.

According to a nano coordination polymer and a preparation method and application thereof, the nano coordination polymer includes: ditiocarb sodium and copper, wherein the ditiocarb sodium and the copper form a polymer through coordination. The nano coordination can be wrapped by a targeting ligand through electrostatic interaction to form a core-shell structure. The preparation method includes steps of: mixing ditiocarb sodium with a stabilizer to obtain a mixed solution, and dripping CuCl.sub.2 into the mixed solution through a constant flow pump to obtain a polymer; and dripping a targeting ligand into the polymer through the constant flow pump; then stirring to obtain the nano coordination polymer. The nano coordination polymer will interfere with the p97 pathway, cause the accumulation of ubiquitinated proteins, and then lead to impaired protein degradation, and finally induce cell apoptosis.

The present disclosure is directed to methods of printing 3-D structures using supramolecular gels, and the structures that result therefrom.

A method for enhancing the conductivity of MOF-5 by the development of an MOF-5 polymer composite material. The composite material incorporates a conductive polymer, preferably polyaniline, in the solvo-thermal synthesis pathway of MOF-5. The electrically conductive MOF-5 composite exhibits electric conductivity three orders of magnitude higher than that of MOF-5 while maintaining the crystallinity, robustness, and thermal stability of MOF-5.

The present invention relates to supramolecular biomedical polymers comprising quadruple hydrogen bonding units and to a process for preparing such a supramolecular biomedical polymer and porous biomedical implants thereof. The supramolecular biomedical polymers are particularly suitable for the production of porous biomedical implants that need high strength, elasticity, durability, and slow biodegradation, e.g. medical implants for living tissue regeneration within a mammal, such as the treatment of cardio-vascular diseases, medical prolapses, and hernias.

Described herein are associative polymers capable of controlling one or more physical and/or chemical properties of non-polar compositions and related compositions, methods and systems.

A block copolymer of the formula R.sub.f-PEG-PAA is disclosed, where R.sub.f comprises a perfluoroalkyl group having at least 3 carbon atoms, bound to an ether oxygen atom directly or through a substituted or unsubstituted alkylene group, PEG is a poly(alkylene glycol) unit having a weight average molecular weight or number average molecular weight of from 1 to 20 kDa, and PAA is one or more poly([meth]acrylic acid) units having a total weight average molecular weight or number average molecular weight of from 0.3 to 10 kDa. A polymer mixture including the block copolymer, a co-hydrogel and a drug delivery vehicle including the polymer mixture, and methods of synthesizing the block copolymer, forming a sol-gel two-phase co-hydrogel, forming a drug delivery vehicle, and delivering a drug to a patient in need thereof are also disclosed.

The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.