The present disclosure relates to a process for the processing of perfluoropolymer materials, and to the use of the resultant products in different potential applications, such as in the medical device field. The process can include, for example, the steps of: (i) dissolving one or more uncured perfluoropolymer materials in a solvent containing one or more liquid perfluorinated solvent(s) to form a solution; (ii) optionally adding one or more porogens and/or one or more functional additives to the solution formed in (i) to form a mixture; (iii) applying the resultant solution or mixture formed in steps (i) and (ii) to a substrate to form one or more partial or continuous deposited layers on the substrate; (iv) curing the perfluoropolymer within the deposited layer to form a perfluoroelastomeric product; and (v) optionally removing the porogen from the perfluoroelastomeric product.

The present disclosure relates to a process for the processing of perfluoropolymer materials, and to the use of the resultant products in different potential applications, such as in the medical device field. The process can include, for example, the steps of: (i) dissolving one or more uncured perfluoropolymer materials in a solvent containing one or more liquid perfluorinated solvent(s) to form a solution; (ii) optionally adding one or more porogens and/or one or more functional additives to the solution formed in (i) to form a mixture; (iii) applying the resultant solution or mixture formed in steps (i) and (ii) to a substrate to form one or more partial or continuous deposited layers on the substrate; (iv) curing the perfluoropolymer within the deposited layer to form a perfluoroelastomeric product; and (v) optionally removing the porogen from the perfluoroelastomeric product.

A substrate for a composite membrane includes a microporous polyolefin membrane for carrying a hydrophilic resin compound within the pores of the microporous membrane wherein: the average pore diameter is 1 nm to 50 nm; the porosity is 50% to 78%; the membrane thickness is 1 μm to 12 μm; and, when a mixed solution of ethanol and water (volume ratio ½) is dripped onto a surface of the microporous polyolefin membrane which has not undergone hydrophilization treatment, the contact angle θ1 between the droplet and the surface is 0 to 90 degrees 1 second after the dripping, and the contact angle θ2 between the droplet and the surface is 0 to 70 degrees 10 minutes after the dripping, and the rate of change of the contact angle ((θ1−θ2)/θ1×100) is 10 to 50%.

An article of manufacture includes a cellular structure having one or more layers that are dispensed in a viscous form. Each of the one or more layers have a plurality of walls that define an array of cells, the array of cells being arranged to create a non-uniform relative density and/or cell geometry across a width and/or a length of the cellular structure, the width and the length being oriented substantially orthogonally to a depth of the cellular structure.

An article of manufacture includes a cellular structure having one or more layers that are dispensed in a viscous form. Each of the one or more layers have a plurality of walls that define an array of cells, the array of cells being arranged to create a non-uniform relative density and/or cell geometry across a width and/or a length of the cellular structure, the width and the length being oriented substantially orthogonally to a depth of the cellular structure.

The present invention relates to a method for producing a three-dimensional ordered porous microstructure. In the method of the invention where the three-dimensional ordered microstructure is produced using the colloidal crystal templating process, the three-dimensional ordered microstructure thus formed is subjected to heat treatment to soften the particles, so as to effectively increase the contact between orderly arranged particles while removing the solvent used to suspend the particles. The present invention further relates to a monolithic column produced thereby. Compared to the monolithic columns produced by conventional methods, the monolithic column according to the invention is characterized in having a higher aspect ratio and a higher pore regularity, while the connecting pores in the column are relatively large in pore size.

The present invention relates to a method for producing a three-dimensional ordered porous microstructure. In the method of the invention where the three-dimensional ordered microstructure is produced using the colloidal crystal templating process, the three-dimensional ordered microstructure thus formed is subjected to heat treatment to soften the particles, so as to effectively increase the contact between orderly arranged particles while removing the solvent used to suspend the particles. The present invention further relates to a monolithic column produced thereby. Compared to the monolithic columns produced by conventional methods, the monolithic column according to the invention is characterized in having a higher aspect ratio and a higher pore regularity, while the connecting pores in the column are relatively large in pore size.

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.