The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

This invention discloses an injectable nanocomposite gel composition and the method of making the composition. The composition is composed of amphiphilic alginate nanoparticle, gel stabilizer, gel crosslinker, and gel structural modifiers. The nanocomposite gel can be manufactured into a form of highly-viscous gel or a solid-like gel, used as a vehicle to carry and deliver pharmaceutically active ingredients with high drug load via injection administration for medical uses.

The present invention provides a hydrophobic alginic acid particle group which is obtained by subjecting a polyvalent metal alginate to a hydrophobization treatment, and which is configured such that the water absorption per 100 g of the particles is lower than the oil absorption per 100 g of the particles.

The present invention relates to the formation of gels. In particular, the present invention is directed to a method of forming a cross-linked polymer hydrogel using competitive ligand exchange.

The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

High performance electrodes for electrochemical devices having a polymer network with an electroactive material chemically attached to a crosslinked polymer matrix are disclosed. A method includes mixing an electrode slurry and forming a polymer network within the electrode slurry. The electrode slurry includes an electroactive material, an electrically conductive filler, a plurality of polymer chains, and a plurality of chemical crosslinking precursors. Each chemically crosslinking precursor is configured to (i) chemically crosslink the plurality of polymer chains and (ii) chemically attach the electroactive material to the plurality of polymer chains.

The present invention is directed to a biodegradable tough adhesive material comprising an interpenetrating networks (IPN) hydrogel comprising a first polymer network and a second polymer network, wherein the first polymer network comprises a first polymer covalently crosslinked with a biodegradable covalent crosslinker and the second polymer network comprises a second polymer crosslinked with ionic or physical crosslinks; a high density primary amine polymer; and a coupling agent. The present invention also provides methods preparing and using the biodegradable tough adhesive material.

The present invention provides amphiphilic polymer particles which are formed from a naturally derived starting material and exhibit hydrophobicity, while maintaining an adequate water absorption. An amphiphilic alginic acid particle group which is obtained by subjecting a polyvalent metal salt of alginic acid to a hydrophobization treatment with use of a hydrophobizing agent, wherein: some metal ions in the polyvalent metal salt of alginic acid are hydrophobized through a chemical bond with the hydrophobizing agent; the contact angle at 30 seconds after dropping a water droplet on the particle group is from 300 to 150°; and the water absorption per 100 g of the particles is not less than the oil absorption per 100 g of the particles.

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine.