The present invention relates to a manufacturing device for manufacturing a large amount of micro-scaffolds for a long period of time such that stable and uniform particles can be fabricated. The manufacturing device comprises: a first solution storage portion for storing a polymer support structure solution; a second solution storage portion for storing an emulsifier solution; a gas storage portion connected to each of the first solution storage portion and the second solution storage portion; a pressure control portion for controlling the pressure of the transporting gas flowing into the first solution storage portion and the second solution storage portion from the pressurization portion, respectively; a scaffold injector portion for receiving the polymer support structure solution and the emulsifier solution provided by the transporting gas, respectively; and a scaffold generating portion for receiving the scaffold dispersion discharged through the scaffold injection portion.

Disclosed are a sustained-release injection formulation containing a biodegradable polymer microcapsule that contains a conjugate of poly-L-lactic acid (hereinafter referred to as “PLLA”) filler and hyaluronic acid (hereinafter referred to as “HA”) and contains a PLLA-HA microcapsule, and a method of preparing the same.

A method of producing biopolymer films is disclosed. The method includes pre-treating a carbon source, preparing a basal media, preparing an inoculum and fermenting the carbon source using the inoculum in the basal media so as to selectively modify the metabolic pathway of the microorganism to produce a biopolymer. Further, the method includes recovering the biopolymer resulting from the step of fermentation and blending the biopolymer with at least one blending agent to produce one or more biopolymer films.

A composite material includes biodegradable and/or renewable materials such as purified milk protein recovered as a byproduct in cheese making processes. The result is a material suitable for three-dimensional (3D) printing and extrusion based polymer processing, with improved properties but that is still environmentally friendly. Purified milk protein may be used to produce composite thermoplastic materials or resins. Additional chemical modification may improve the blending of purified milk protein.

A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

The invention refers to a method for producing expanded polymer pellets, which comprises the following steps: melting a polymer comprising a polyamide; adding at least one blowing agent; expanding the melt through at least one die for producing an expanded polymer; and pelletizing the expanded polymer. The invention further concerns polymer pellets produced with the method as well as their use, e.g. for the production of cushioning elements for sports apparel, such as for producing soles or parts of soles of sports shoes. A further aspect of the invention concerns a method for the manufacture of molded components, comprising loading pellets of an expanded to polymer material into a mold, and connecting the pellets by providing heat energy, wherein the expanded polymer material of the pellets or beads comprises a chain extender. The molded components may be used in broad ranges of application.

The present disclosure includes composite microparticles for magnetically triggered release of a biologically active agent. Also included are systems including the biocompatible composite microparticles and an alternating current (AC) magnetic field generator to magnetically trigger release of a biologically active agent from the microparticles. The present disclosure further includes methods of delivering a biologically active agent to a patient in vivo using the microparticles and systems of the present disclosure. The present disclosure also includes methods of making biocompatible composite microparticles of the present disclosure for magnetically triggered release of a biologically active agent.

Disclosed herein are embodiments of a method for making recyclable polymers and a method for decomposing the polymers back to the monomers which can then be reused. The polymer are stable to aqueous and/or acid conditions and may have a formula II

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The method to decompose the polymer back to the monomers may comprise heating the polymer in a protic organic solvent.

The invention presented in this document relates to processes for the preparation of a formulation containing poly(lactic acid) (PLA) and aliphatic and/or aromatic polyesters which plasticize it, and its use in monofilaments and films. The presence of polyesters does not remove the biodegradability and composting characteristics of the raw materials used in the formulation. The invention also concerns products that use the formulation.

Polylactide (PLA) parts can be crystallized via two procedures. In the first procedure, i.e. a 2-step post-mold annealing process, the complete crystallization of PLA parts can be done after molding in a secondary operation called as post-mold annealing to make higher heat-resistant PLA parts. There are limitations to this 2-step operation, namely, a) warpage of parts with complex geometries, and b) scaling up higher production volume times. In the second procedure, i.e. 1-step in-mold annealing process, the complete crystallization of PLA parts can be done in the mold itself by holding the temperature of the mold at the crystallization temperature of PLA which is about 100° C. The 1-step in-mold annealing process using a masterbatch blended with neat PLA results in a highly crystalline article produced in a significantly lower cycle time.