C08J2405/04

Crosslinked Hydrogel for Muscle Stem Cell Culture and Preparation Method and Use Thereof
20220333080 · 2022-10-20 ·

The present disclosure discloses a crosslinked hydrogel for muscle stem cell culture and a preparation method and use thereof, and belongs to the technical field of biological food materials. The preparation method includes: dissolving collagen to prepare a solution and adding a certain amount of alginate and heparan sulfate proteoglycan for being uniformly mixed with the collagen solution; and adding ε-PL and TGase into the solution, uniformly stirring, and putting a slurry into a mold for crosslinking to obtain the hydrogel. The hydrogel is prepared by linking the collagen, the polylysine and the heparan sulfate proteoglycan using the TGase to form covalent crosslinking, and forming a compact three-dimensional “egg box” network structure through a physical electrostatic interaction between the polylysine and the alginate. The hydrogel can enhance the absorption to nutrient substances by the muscle stem cells and facilitate the growth of the muscle stem cells. The double-network crosslinked hydrogel has the potential to be a scaffold for the growth of muscle stem cells for cultured meat from stem cells.

BIODEGRADABLE FOAM WITH ALGINATE
20230104197 · 2023-04-06 ·

A foam is described. The foam comprising a polymer matrix including at least one of chitin, chitosan, or chitosan oligosaccharide. The polymer matrix is porous. The foam further comprising alginate. The foam has a density of less than 1 g/cm.sup.3. A method of making foam is described. The method comprising dissolving at least one of chitin, chitosan, or chitosan oligosaccharide in a first solution, dissolving alginate in a second solution that is alkaline and separate from the first solution, mixing the first solution and the second solution together to form a foam precursor, and drying the foam precursor to form the foam.

Preparation Method and Use of Crosslinked Hydrogel for Muscle Stem Cell Culture
20220315711 · 2022-10-06 ·

The present disclosure discloses a preparation method and use of a crosslinked hydrogel for muscle stem cell culture, and belongs to the technical field of biological food materials. Chitosan, alginate, dextran and Ca.sup.2+ are crosslinked through physical crosslinking to form a double-network hydrogel with a high mechanical strength, the hydrogel is coated with heparin and collagen through dip coating, such that the hydrogel can immobilize growth factors and adhere to cells. Meanwhile, extracted primary muscle stem cells are inoculated onto the hydrogel and cultured in a growth medium (79% of DMEM, 10% of FBS and 1% of double antibodies) for 24 h. The cells are cultured in an incubator with a differential medium (97% of DMEM, 2% of horse serum and 1% of double antibodies) for 7 d. The hydrogel can enhance the absorption to nutrient substances by the muscle stem cells and facilitate growth of the muscle stem cells. The double-network hydrogel has the potential to be a scaffold for growth of muscle stem cells for cultured meat from stem cells.

Stretchable ionic hydrogel with high thermopower for low-grade heat harvesting

An ionic thermoelectric (i-TE) hydrogel that converts heat into electricity based on the Soret effect, and devices and methods incorporating the ionic thermoelectric hydrogel. The ionic thermoelectric hydrogel includes poly(acrylamide) crosslinked with an alginate, 1-ethyl-3-methylimidazolium tetrafluoroborate, and a poly glycol.

METHOD OF PRODUCING A MINERAL WOOL PRODUCT COMPRISING A MULTIPLE OF LAMELLAE AND A PRODUCT OF SUCH KIND
20230166492 · 2023-06-01 ·

A method and a mineral wool product include a multiple of lamellae, such as a sandwich panel core. The product includes a plurality of lamellae cut from a mineral wool web, and bonded together by applying an adhesive on the surfaces of two adjacent lamellae to form a web-like product, wherein the adhesive comprises at least one hydrocolloid.

Cross-Linkable Polymer, Hydrogel, and Method of Preparation Thereof

The invention relates to a cross-linkable polymer including a base polymer including functional groups at least some of which have been reacted with a first organic molecule including a cross-linkable unit and with a second organic molecule capable of bonding to organic and/or inorganic substrates. The invention further relates to a hydrogel including the cross-linkable polymer that includes cross-linkable polymer strands, wherein at least some of the cross-linkable units of different cross-linkable polymer strands have reacted to form a covalent bond thereby forming a covalently linked network. The invention further relates to a method for the preparation of the hydrogel and to the use of the hydrogel.

POLYVINYL ALCOHOL HYDROGEL HAVING ASYMMETRIC PORE SIZE

The present invention relates to a polyvinyl alcohol hydrogel having an asymmetric pore size. the pore size of the upper surface of the polyvinyl alcohol hydrogel is 1-30 μm, the pore size of lower surface thereof is 50-300 μm, and the pore size of the hydrogel gradually increases from the upper surface to the lower surface. The polyvinyl alcohol hydrogel in the present invention has excellent biocompatibility, and has functions of blocking bacteria, anti-adhesion, the absorption of exudate, promoting wound healing, observing in situ of wound healing process and the like.

HYDROGEL COMPOSITION WITH THERMOS-SENSITIVE AND IONIC REVERSIBLE PROPERTIES, CARRIER, METHOD FOR PREPARING AND METHOD OF USE THEREOF
20220135748 · 2022-05-05 ·

The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

FOAM COMPOSITIONS, FOAM MATRICES AND METHODS
20230241282 · 2023-08-03 ·

Disclosed herein are matrices, compositions and methods of making matrices. The matrix comprises a biomolecule and the matrix is a dried, cross-linked foam. The matrix is not lyophilized. The method comprises foaming the composition, crosslinking the composition and drying the composition. Matrices disclosed herein are useful as wound dressings and treating wounds.

COMPOSITION, PREPARATION METHOD FOR AND APPLICATION OF COMPOSITION, AND SELF-HEALING METHOD FOR WELL CEMENTING IN OIL/GAS FIELD

Described are a self-healing composition, and a preparation method for and an application of the composition. The composition is of a core-shell structure; the core contains a hydrogenated styrenic thermoplastic elastomer polymer and an inorganic filler; the shell contains a hydrophilic polymer; the composition has a density of 1.2-2 g/cm.sup.3, a water contact angle of no more than 90°, and a diesel oil and/or natural gas absorption expansion ratio of 5-15 times. By coating the hydrogenated styrenic thermoplastic elastomer and the inorganic filler with the hydrophilic (surface polarized) polymer, a core-shell structure is formed. When the composition is used for well cementing in an oil/gas field, the composition has a density and compatibility matching cement mortar and thus can form a uniform and stable cement slurry for well cementing in the oil/gas field, and has excellent oil/gas absorption expansion performance and thus can expand after absorbing oil/gas to perform self-healing.