The present invention encompasses compounds of formula (I)

##STR00001##

wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.

There are provided stretchable solid-state electroactive polymer actuators (SSEPA) using electroactive polymers that convert between electrical energy and mechanical energy and having solid-state polymer electrolytes. More particularly, there are provided electroactive polymer (EAP) compositions comprising: 15-60 wt. % of a film-forming polymer; 5-40 wt. % of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and 10-40 wt. % of a plasticizer, solid-state polymer electrolyte (SPE) compositions comprising: 20-60 wt. % of a plasticizer, 10-60 wt. % of a film-forming polymer and 5-25 wt. % of an ionizable salt. The use of these EAP and SPE compositions in electromechanical devices, such as solid-state actuators, generators, sensors, and other energy transducers in various applications are also disclosed.

There are provided stretchable solid-state electroactive polymer actuators (SSEPA) using electroactive polymers that convert between electrical energy and mechanical energy and having solid-state polymer electrolytes. More particularly, there are provided electroactive polymer (EAP) compositions comprising: 15-60 wt. % of a film-forming polymer; 5-40 wt. % of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and 10-40 wt. % of a plasticizer, solid-state polymer electrolyte (SPE) compositions comprising: 20-60 wt. % of a plasticizer, 10-60 wt. % of a film-forming polymer and 5-25 wt. % of an ionizable salt. The use of these EAP and SPE compositions in electromechanical devices, such as solid-state actuators, generators, sensors, and other energy transducers in various applications are also disclosed.

A conductive nanocomposite which contains a mixed polymer matrix which contains a rubber and a polyether, carbon nanoparticles, and transition metal nanoparticles. The conductive nanocomposite has a nonlinear relationship between resistivity and temperature characterized by an exponential increase reaching a peak resistivity followed by an exponential decrease as temperature increases. Also disclosed is a method of forming the conductive nanocomposite involving mixing the components, aging, and pressing. The conductive nanocomposite forms a component of a heater that is self-regulating as a result of the nonlinear relationship between resistivity and temperature of the conductive nanocomposite. The nanocomposite also forms a component of a thermistor.

A conductive nanocomposite which contains a mixed polymer matrix which contains a rubber and a polyether, carbon nanoparticles, and transition metal nanoparticles. The conductive nanocomposite has a nonlinear relationship between resistivity and temperature characterized by an exponential increase reaching a peak resistivity followed by an exponential decrease as temperature increases. Also disclosed is a method of forming the conductive nanocomposite involving mixing the components, aging, and pressing. The conductive nanocomposite forms a component of a heater that is self-regulating as a result of the nonlinear relationship between resistivity and temperature of the conductive nanocomposite. The nanocomposite also forms a component of a thermistor.

The present invention encompasses compounds of formula (I) wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates. ##STR00001##

The present invention encompasses compounds of formula (I) wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates. ##STR00001##

Thermally conductive polymer (TCP) resin compositions are described, comprising components (X) and (Y): 90 to 99.9% component (X) comprising components (I) and (II): 60 to 85% matrix polymer (I) comprising styrenic polymers (F) selected from: ABS resins, ASA resins, and elastomeric block copolymers of the structure (S(B/S)).sub.nS; 15 to 40% thermally conductive filler material (II) (D.sub.50 1 to 200 ), consisting of a ceramic material and/or graphite; 0.1 to 10% chemical foaming agent (Y). Shaped articles made thereof can be used for automotive applications, as a heat sink for high performance electronics, LED sockets or electrical and electronic housings.

Thermally conductive polymer (TCP) resin compositions are described, comprising components (X) and (Y): 90 to 99.9% component (X) comprising components (I) and (II): 60 to 85% matrix polymer (I) comprising styrenic polymers (F) selected from: ABS resins, ASA resins, and elastomeric block copolymers of the structure (S(B/S)).sub.nS; 15 to 40% thermally conductive filler material (II) (D.sub.50 1 to 200 ), consisting of a ceramic material and/or graphite; 0.1 to 10% chemical foaming agent (Y). Shaped articles made thereof can be used for automotive applications, as a heat sink for high performance electronics, LED sockets or electrical and electronic housings.

Provided is an antistatic material that contains a mixture of first alkoxysilane that contains at least one alkoxy group and at least one polymerizable organic functional group, second alkoxysilane that contains at least one alkoxy group and does not contain a polymerizable organic functional group, a solvent, an acidic catalyst, and an ionic compound.