Temperature responsive phase change bio-complexes (PCBC) with tunable physicochemical properties and preparation method thereof. The phase change bio-complexes consist of a phase change material (PCM) (or mixture of PCMs) and a polysaccharide (or combination of polysaccharides). The polysaccharide provides mechanical and thermal stabilization and the PCM provides temperature responsive properties to the complexation. In order to undergo complexation with polysaccharides, sugar alcohols and salt hydrates classifications of PCMs are preferred which results in compatibility and homogeneity of the bio-complexes. Addition of multivalent cations (water soluble salts) and/or salts of an acid tunes the thermophysical properties of the bio-complexes such as tunable temperature and latent heat of fusion and structural and thermal stability. These environmentally benign phase change bio-complexes can be applied in different form-stable formats such as powdered, films, pellets, sheets, beads, sponge etc. for thermal management purposes including thermal energy storage and thermal protection via heat absorbing-releasing, for instance, in building, packaging, electronics, temperature sensitive items (black boxes) and wearables.

Temperature responsive phase change bio-complexes (PCBC) with tunable physicochemical properties and preparation method thereof. The phase change bio-complexes consist of a phase change material (PCM) (or mixture of PCMs) and a polysaccharide (or combination of polysaccharides). The polysaccharide provides mechanical and thermal stabilization and the PCM provides temperature responsive properties to the complexation. In order to undergo complexation with polysaccharides, sugar alcohols and salt hydrates classifications of PCMs are preferred which results in compatibility and homogeneity of the bio-complexes. Addition of multivalent cations (water soluble salts) and/or salts of an acid tunes the thermophysical properties of the bio-complexes such as tunable temperature and latent heat of fusion and structural and thermal stability. These environmentally benign phase change bio-complexes can be applied in different form-stable formats such as powdered, films, pellets, sheets, beads, sponge etc. for thermal management purposes including thermal energy storage and thermal protection via heat absorbing-releasing, for instance, in building, packaging, electronics, temperature sensitive items (black boxes) and wearables.

The present invention provides compositions, and related kits and methods, for formation of hydrogels. The compositions comprise one or more chemically crosslinkable agents dissolved in an aqueous solution to form a precursor solution. The chemically crosslinkable agents useful in the present invention are selected from polymers modified with a molecule selected from acrylate, maleimide, vinylsulfone, N-hydroxysuccinimide, aldehyde, ketone, carbodiimide, carbonate, iodoacetyl, mercaptonicotinamide, quinone, thiol, amine, and combinations thereof. The precursor solution is characterized as being in an aqueous form at a non-physiologic physical-chemical condition and undergoing gelation when in contact with another fluid or body at a physiologic physical-chemical condition.

The present invention provides compositions, and related kits and methods, for formation of hydrogels. The compositions comprise one or more chemically crosslinkable agents dissolved in an aqueous solution to form a precursor solution. The chemically crosslinkable agents useful in the present invention are selected from polymers modified with a molecule selected from acrylate, maleimide, vinylsulfone, N-hydroxysuccinimide, aldehyde, ketone, carbodiimide, carbonate, iodoacetyl, mercaptonicotinamide, quinone, thiol, amine, and combinations thereof. The precursor solution is characterized as being in an aqueous form at a non-physiologic physical-chemical condition and undergoing gelation when in contact with another fluid or body at a physiologic physical-chemical condition.

The present invention provides compositions, and related kits and methods, for formation of hydrogels. The compositions comprise one or more chemically crosslinkable agents dissolved in an aqueous solution to form a precursor solution. The chemically crosslinkable agents useful in the present invention are selected from polymers modified with a molecule selected from acrylate, maleimide, vinylsulfone, N-hydroxysuccinimide, aldehyde, ketone, carbodiimide, carbonate, iodoacetyl, mercaptonicotinamide, quinone, thiol, amine, and combinations thereof. The precursor solution is characterized as being in an aqueous form at a non-physiologic physical-chemical condition and undergoing gelation when in contact with another fluid or body at a physiologic physical-chemical condition.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure and contains a hydrophobic solvent.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure and contains a hydrophobic solvent.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure, a hydrophobic solvent, and a crosslinked particle containing one or more compounds selected from the group consisting of a crosslinked protein and a crosslinked polysaccharide.

The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure, a hydrophobic solvent, and a crosslinked particle containing one or more compounds selected from the group consisting of a crosslinked protein and a crosslinked polysaccharide.

The present invention provides crosslinking pairs of hydrogel precursor polymers, dynamic covalent hydrogels prepared from such crosslinking pairs of hydrogel precursors, pharmaceutical compositions comprising such precursors or hydrogels and uses thereof in a variety of applications.