This invention relates to the flexible packaging, either as sheet, roll, bag, sachet, or other forms, which is biodegradable and edible, and could be used as packaging for solid, semisolid, and liquid, which is featured by the composition of biopolymers, at least two of different natural and renewable biopolymers, and the manufacturing method thereof.

A biodegradable aliphatic-aromatic polyester for the production of packaging films, having a Poisson's ratio (RVE) between 800 and 1700, comprising units of at least one dicarboxylic acid and at least one diol, in which Mn≥40000 and Mw/q≤90000, in which q is the percentage by weight of polyester oligomers having a molecular weight≤10000.

A biodegradable aliphatic-aromatic polyester for the production of packaging films, having a Poisson's ratio (RVE) between 800 and 1700, comprising units of at least one dicarboxylic acid and at least one diol, in which Mn≥40000 and Mw/q≤90000, in which q is the percentage by weight of polyester oligomers having a molecular weight≤10000.

A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.

A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.

A composition for treating a wound includes graphene oxide (GO) and hyaluronic acid (HA) that are covalently linked, XAV939, and water. The composition can also include a surfactant, such as PEG. The composition can be topically administered to a subject to treat a wound of the subject. Methods of treating a wound using the composition are also provided.

A composition for treating a wound includes graphene oxide (GO) and hyaluronic acid (HA) that are covalently linked, XAV939, and water. The composition can also include a surfactant, such as PEG. The composition can be topically administered to a subject to treat a wound of the subject. Methods of treating a wound using the composition are also provided.

A process for producing a composition comprising a crosslinked hydrogel is proposed. The process comprises providing a container body (2), wherein the container body (2) has a body inner wall (21) and a body outer wall (22), wherein the body inner (21) wall is configured to be tempered, filling of a fluid (7) comprising at least a mixture of a polymer and water into the container body (2), and agitating the fluid. For crosslinking of the fluid (7), a container insert (3) is provided, the container insert (3) having an insert outer wall (32) which is configured to be tempered and a container assembly (1) is formed by inserting the container insert (3) into the container body (2) so that the insert outer wall (32) of the container insert (3) and the body inner wall (21) of the container body (2) are separated by a gap (9) of constant width and define a volume (6) for receiving the fluid (7). Crosslinking of the fluid (7) is then performed while tempering the insert outer wall (32) and the body inner wall (21) to form a crosslinked hydrogel.

A demineralized bone matrix (DBM) scaffold product comprising a plurality of elongate demineralised bone fibres mechanically interconnected with one another in a regular and repeating pattern.

A demineralized bone matrix (DBM) scaffold product comprising a plurality of elongate demineralised bone fibres mechanically interconnected with one another in a regular and repeating pattern.