A method and kit for the apical sealing an tooth root canal and for improving root canal fillings are described. Also described is a method for using bone glue as an apical stop for obturating root canals.

A method and kit for the apical sealing an tooth root canal and for improving root canal fillings are described. Also described is a method for using bone glue as an apical stop for obturating root canals.

This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.

This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.

The present invention relates to a scaffold for artificial organs using a water-soluble non-degradable acrylic polymer and a water-insoluble non-degradable acrylic polymer, which are acrylic synthetic polymers, and a preparation method thereof.

The acrylic monomer or polymer-based scaffold of the present invention improves the disadvantages of the natural polymer-based scaffolds, allowing degradation of specific sites in vivo and easy cell adhesion, and since it is possible to control mechanical properties, it is possible to implement mechanical properties and morphology suitable for where to use and purpose of use. In addition, the present invention can be applied as a bio material for artificial organs such as artificial cornea, artificial liver, artificial heart, artificial cartilage or artificial bone tissue, which requires maintenance of physical properties, high cell compatibility and stability in the body.

The present invention relates to a scaffold for artificial organs using a water-soluble non-degradable acrylic polymer and a water-insoluble non-degradable acrylic polymer, which are acrylic synthetic polymers, and a preparation method thereof.

The acrylic monomer or polymer-based scaffold of the present invention improves the disadvantages of the natural polymer-based scaffolds, allowing degradation of specific sites in vivo and easy cell adhesion, and since it is possible to control mechanical properties, it is possible to implement mechanical properties and morphology suitable for where to use and purpose of use. In addition, the present invention can be applied as a bio material for artificial organs such as artificial cornea, artificial liver, artificial heart, artificial cartilage or artificial bone tissue, which requires maintenance of physical properties, high cell compatibility and stability in the body.

The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.

The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.

Disclosed herein is a medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of (a) an isocyanate-bearing material on or covalently bonded to the substrate and (b) a heparin molecule selected from one of the formulae in the claims. The current invention also relates to a method of forming the medical device, which may be useful as heart stent or intravascular stent that is hemocompatible for preventing the formation of blood clots.

Disclosed herein is a medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of (a) an isocyanate-bearing material on or covalently bonded to the substrate and (b) a heparin molecule selected from one of the formulae in the claims. The current invention also relates to a method of forming the medical device, which may be useful as heart stent or intravascular stent that is hemocompatible for preventing the formation of blood clots.