Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site. The device includes an absorption component, a cannula, and a discharge component configured to be implanted in a subcutaneous location while the absorption component is not subcutaneous. The cannula can extend through or across the skin of a patient. The discharge component can includes one or more multi-layered, flexible mesh sheets, which are coupled to cells.

An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site. The device includes an absorption component, a cannula, and a discharge component configured to be implanted in a subcutaneous location while the absorption component is not subcutaneous. The cannula can extend through or across the skin of a patient. The discharge component can includes one or more multi-layered, flexible mesh sheets, which are coupled to cells.

Medical devices such as stents, stent grafts, and balloon catheters include an exterior surface, an intermediate layer overlying the exterior surface, and a coating layer overlying the intermediate layer, wherein the intermediate layer comprises a poly(p xylylene); and the coating layer comprises a hydrophobic therapeutic agent and at least one additive. The intermediate layer may be a parylene. The therapeutic agent may include paclitaxel, rapamycin, or combinations thereof. The intermediate layer may affect the release kinetics of the drug from the balloon, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, the particle size of drug of a therapeutic layer in the coating layer, or may release a micron layer of parylene with the drug to prohibit washout by the blood stream after delivery. For example, the effects caused by the intermediate layer may increase the retention time and amount of therapeutic agent in tissue.

Medical devices such as stents, stent grafts, and balloon catheters include an exterior surface, an intermediate layer overlying the exterior surface, and a coating layer overlying the intermediate layer, wherein the intermediate layer comprises a poly(p xylylene); and the coating layer comprises a hydrophobic therapeutic agent and at least one additive. The intermediate layer may be a parylene. The therapeutic agent may include paclitaxel, rapamycin, or combinations thereof. The intermediate layer may affect the release kinetics of the drug from the balloon, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, the particle size of drug of a therapeutic layer in the coating layer, or may release a micron layer of parylene with the drug to prohibit washout by the blood stream after delivery. For example, the effects caused by the intermediate layer may increase the retention time and amount of therapeutic agent in tissue.

A composite expandable medical balloon comprising a base balloon, the base balloon comprising a coextrusion, the coextrusion comprising an inner layer formed from an elastomeric polymer and an outer layer formed from a thermoplastic polymer a fiber braid disposed along the base balloon, the fiber braid comprising at least one polymeric fiber disposed over the base balloon, wherein the base balloon is designed to exhibit minimal delamination between the inner layer the outer layer of the base balloon, and methods of making the same.

A composite expandable medical balloon comprising a base balloon, the base balloon comprising a coextrusion, the coextrusion comprising an inner layer formed from an elastomeric polymer and an outer layer formed from a thermoplastic polymer a fiber braid disposed along the base balloon, the fiber braid comprising at least one polymeric fiber disposed over the base balloon, wherein the base balloon is designed to exhibit minimal delamination between the inner layer the outer layer of the base balloon, and methods of making the same.

Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.