Closed disposable seeding systems with improved seeding chambers permitting uniform seeding of a scaffold or graft with patient's cells are provided. The seeding chambers with a variable width along the length of the chamber, or a minimal gap between the scaffold and chamber wall, provide an improvement of the prior seeding chambers of closed disposable seeding systems by providing faster and more efficient and uniform seeding of the grafts and scaffolds. Also described are scaffolds with biomechanical and structural properties permitting spontaneous reversal of stenosis and neotissue formation as the graft degrades yielding a scaffold-free neovessel.

Transluminally implantable cardiac valves configured for use in cardiac valve replacement and/or cardiac valve exclusion that are capable of percutaneous delivery on low-profile catheters having 15 French size or less. The implantable cardiac valves are fabricated of from a unitary metal material to form a lattice frame support having a main body portion and valve leaflet portion, and a plurality of elongate biasing arm members. A polymer coating or covering is disposed on the valve leaflet portion and the elongate biasing arm members and subtends space between adjacent pairs of elongate biasing arm members to form valve leaflet portions in which the elongate biasing arms and the polymer coating operate to share a mechanical load thereupon.

Transluminally implantable cardiac valves configured for use in cardiac valve replacement and/or cardiac valve exclusion that are capable of percutaneous delivery on low-profile catheters having 15 French size or less. The implantable cardiac valves are fabricated of from a unitary metal material to form a lattice frame support having a main body portion and valve leaflet portion, and a plurality of elongate biasing arm members. A polymer coating or covering is disposed on the valve leaflet portion and the elongate biasing arm members and subtends space between adjacent pairs of elongate biasing arm members to form valve leaflet portions in which the elongate biasing arms and the polymer coating operate to share a mechanical load thereupon.

A biodegradable hairpin contains: a first clip, a second clip, and a C-shaped flexible retainer. The C-shaped flexible retainer includes a first leg, a second leg, an opening, a peak portion, a first shoulder, and a second shoulder. An inner wall of the C-shaped flexible retainer extends to the first leg and the second leg from the peak portion along a parabolic track, such that a thickness of a cross section of the peak portion is 1.666 times more than a thickness of a cross section of the first leg and a thickness of a cross section of the second leg. The biodegradable hairpin is made of any one or a combination of at least two of Bio-Polybutylene Succinate (PBS), Polylactic acid (PLA), D-polylactide (PDLA), toughener, and nucleating agent, such that the biodegradable hairpin has ductility, malleability, and toughness.

A biodegradable hairpin contains: a first clip, a second clip, and a C-shaped flexible retainer. The C-shaped flexible retainer includes a first leg, a second leg, an opening, a peak portion, a first shoulder, and a second shoulder. An inner wall of the C-shaped flexible retainer extends to the first leg and the second leg from the peak portion along a parabolic track, such that a thickness of a cross section of the peak portion is 1.666 times more than a thickness of a cross section of the first leg and a thickness of a cross section of the second leg. The biodegradable hairpin is made of any one or a combination of at least two of Bio-Polybutylene Succinate (PBS), Polylactic acid (PLA), D-polylactide (PDLA), toughener, and nucleating agent, such that the biodegradable hairpin has ductility, malleability, and toughness.

This invention relates to a biodegradable polymer composition which is particularly suitable for use in the manufacture of articles having a high heat deflection temperature (HDT) by injection moulding and thermoforming.

This invention relates to a biodegradable polymer composition which is particularly suitable for use in the manufacture of articles having a high heat deflection temperature (HDT) by injection moulding and thermoforming.

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

An intraocular lenses having a plurality of drug-containing microspheres attached to the intraocular lens. The intraocular lenses can be used for patients undergoing cataract surgery and reduces the need for recurrent surgery, follow-up treatment or postoperative eye-drops. Also provides a method for manufacturing such an intraocular lens and the use of an intraocular lens in the treatment of cataract.