An intraocular lenses having a plurality of drug-containing microspheres attached to the intraocular lens. The intraocular lenses can be used for patients undergoing cataract surgery and reduces the need for recurrent surgery, follow-up treatment or postoperative eye-drops. Also provides a method for manufacturing such an intraocular lens and the use of an intraocular lens in the treatment of cataract.

The disclosure relates to light barrier compositions, methods of making the compositions, articles prepared from the compositions, and methods of making the articles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The disclosure relates to light barrier compositions, methods of making the compositions, articles prepared from the compositions, and methods of making the articles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

The present application provides a dispersion dispersed satisfactorily cellulose nanofibers, powdery cellulose nanofibers obtained by pulverizing thereof, a resin composition obtained by blending thereof and a molding raw material for a 3D printer by using thereof. It is possible to obtain a composition uniformly finely dispersed the cellulose nanofibers by treating a mixture containing unmodified cellulose nanofibers and a dispersant using a high speed agitating Medialess disperser, and followed by pulverizing the composition to blend with a resin and a rubber component. Also, a resin composition improved in mechanical properties and heat resistance, obtained by blending the powdery cellulose nanofibers above with a thermoplastic resin or a thermosetting resin, is useful as a molding material for a 3D printer.

The present application provides a dispersion dispersed satisfactorily cellulose nanofibers, powdery cellulose nanofibers obtained by pulverizing thereof, a resin composition obtained by blending thereof and a molding raw material for a 3D printer by using thereof. It is possible to obtain a composition uniformly finely dispersed the cellulose nanofibers by treating a mixture containing unmodified cellulose nanofibers and a dispersant using a high speed agitating Medialess disperser, and followed by pulverizing the composition to blend with a resin and a rubber component. Also, a resin composition improved in mechanical properties and heat resistance, obtained by blending the powdery cellulose nanofibers above with a thermoplastic resin or a thermosetting resin, is useful as a molding material for a 3D printer.

Disclosed herein are devices for use in transplanting cells. The devices can include a housing defining a cavity; and a support structure separating the cavity into a cell chamber and a reservoir chamber, wherein the support structure comprises a membrane for fluid communication between the cell chamber and reservoir chamber. The cell chamber can define a first opening comprising a microstructure containing an array of micro-channels, each having a diameter to facilitate growth of vascular tissues; and an array of micro-reservoirs, each having a diameter to facilitate housing of cell aggregates individually. The membrane can define a surface area that is at least 50% of a total surface area of the support structure. Methods of treating a subject for a disease condition, such as diabetes, are also disclosed.

Disclosed herein are devices for use in transplanting cells. The devices can include a housing defining a cavity; and a support structure separating the cavity into a cell chamber and a reservoir chamber, wherein the support structure comprises a membrane for fluid communication between the cell chamber and reservoir chamber. The cell chamber can define a first opening comprising a microstructure containing an array of micro-channels, each having a diameter to facilitate growth of vascular tissues; and an array of micro-reservoirs, each having a diameter to facilitate housing of cell aggregates individually. The membrane can define a surface area that is at least 50% of a total surface area of the support structure. Methods of treating a subject for a disease condition, such as diabetes, are also disclosed.

Disclosed herein are methods of making active, food-grade packaging resins using a reactive extrusion step that involves reacting a polymeric material with a ligand and one of a cross-linking agent and a radical initiator in an extruder, under temperature and pressure conditions effective to cause covalent binding of the ligand to the polymeric material by a linker that is the reaction product of the cross-linking agent or by direct bond formation between the ligand and the polymeric material, and then extruding the active, food-grade packaging resin. Also disclosed are the active packaging resins obtained from such methods, methods of forming food packaging materials from the active packaging resins, the food packaging materials that contain the active packaging resins, and methods of packaging perishable food in those food packaging materials.