The present invention relates to an implantable device, in particular for wall repair comprising a reinforcing textile implant having first and second surfaces, a bioadhesive coating to coat said first surface at least in part, said coating comprising at least one ionic, cross-linked bioadhesive polymer selected from among the following polymers: an acrylic acid polymer, methacrylic acid polymer, itaconic acid polymer, maleic acid polymer or maleic anhydride polymer having an adhesive function that can be activated in an aqueous medium.

The present invention relates to an implantable device, in particular for wall repair comprising a reinforcing textile implant having first and second surfaces, a bioadhesive coating to coat said first surface at least in part, said coating comprising at least one ionic, cross-linked bioadhesive polymer selected from among the following polymers: an acrylic acid polymer, methacrylic acid polymer, itaconic acid polymer, maleic acid polymer or maleic anhydride polymer having an adhesive function that can be activated in an aqueous medium.

A graphene-based membrane and a method of producing the same are disclosed. The graphene-based membrane may include a graphene-polymer composite, wherein the graphene-polymer composite may consist of an amine functionalized graphene and a polymer containing an anhydride group as a linker for linking the amine functionalized graphene to the polymer. The graphene-based membrane may be constructed of a single-layer. A method may include reacting a polymer containing an anhydride with an amine functionalized graphene in presence of a solvent to form an intermediate product; and thermal imidizing the intermediate product to form a graphene grafted polymer composite for use in fabricating a graphene-based membrane.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

Subchondral bone analog materials and osteochondral constructs that incorporate the subchondral bone analogs are described. The subchondral bone analog materials include a biodegradable matrix, calcium phosphate particles (e.g., hydroxy apatite) and bioactive glass particles. The materials can exhibit sufficient mechanical strength and biochemical properties such that the materials can support boney integration and healing. Osteochondral constructs can include a first layer of the subchondral bone analog material, a second layer of a calcified cartilage analog material, and a third layer of a cartilage analog material.

Subchondral bone analog materials and osteochondral constructs that incorporate the subchondral bone analogs are described. The subchondral bone analog materials include a biodegradable matrix, calcium phosphate particles (e.g., hydroxy apatite) and bioactive glass particles. The materials can exhibit sufficient mechanical strength and biochemical properties such that the materials can support boney integration and healing. Osteochondral constructs can include a first layer of the subchondral bone analog material, a second layer of a calcified cartilage analog material, and a third layer of a cartilage analog material.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

The invention relates to a powder coating composition for low temperature curing that can be used on temperature sensitive substrates and, despite of the low curing temperature, has excellent flow properties and forms a coating with excellent appearance and nevertheless also good mechanical and weathering properties. The invention also relates to an advantageous process for the manufacture of the powder coating composition. Said powder coating composition comprises a poly-acid functional polyester component A, a poly-epoxy functional component B, a poly-anhydride functional component C and a thermosetting curing catalyst D. The invention also relates to a polyester for use in the powder coating compositions according to the invention, in particular for durable powder coatings.