There are provided PVP-PLA block copolymers as defined in Formula (I): I wherein, x is an initiator alcohol having a boiling point greater than 145° C., n is, on average, from 20 and 40, and m is, on average, from 10 and 40, wherein the block copolymers have a number average molecular weight (M.sub.n) of at least 3000 Da. Polymers demonstrating flexibility in formulating multiple low-solubility active pharmaceutical ingredients (APIs) are described. Liquid and dry pharmaceutical formulations comprising an API are described, along with delivery methods, uses, and kits. APIs may include, e.g. flurbiprofen, celecoxib, acetaminophen, or propofol. Also provided is a method of synthesizing the PVP-PLA block copolymers by (i) initiating polymerization of D,L-Lactide from the initiator alcohol x to form poly(lactic acid), adding a xanthate to form a PLA macroinitiator, and polymerizing NVP onto the PLA macroinitiator, by controlled polymerization, to form the block copolymer compound of Formula (I). ##STR00001##

The invention relates to a non-cross-linked copolymer foam with polyamide blocks and polyether blocks, wherein: the polyamide blocks of the copolymer have an average molar mass of from 200 to 1,500 g/mol; the polyether blocks of the copolymer have an average molar mass of from 800 to 2,500 g/mol; and the weight ratio of the polyamide blocks to the polyether blocks of the copolymer is from 0.1 to 0.9. The invention also relates to a method for manufacturing said foam and items manufactured from said foam.

There are provided PVP-PLA block copolymers as defined in Formula (I): I wherein, x is an initiator alcohol having a boiling point greater than 145° C., n is, on average, from 20 and 40, and m is, on average, from 10 and 40, wherein the block copolymers have a number average molecular weight (M.sub.n) of at least 3000 Da. Polymers demonstrating flexibility in formulating multiple low-solubility active pharmaceutical ingredients (APIs) are described. Liquid and dry pharmaceutical formulations comprising an API are described, along with delivery methods, uses, and kits. APIs may include, e.g. flurbiprofen, celecoxib, acetaminophen, or propofol. Also provided is a method of synthesizing the PVP-PLA block copolymers by (i) initiating polymerization of D,L-Lactide from the initiator alcohol x to form poly(lactic acid), adding a xanthate to form a PLA macroinitiator, and polymerizing NVP onto the PLA macroinitiator, by controlled polymerization, to form the block copolymer compound of Formula (I).

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Amphiphilic biopolymers have been synthesized by grafting lignin onto PLGA to form graft polymers, which can then be further assembled into polymeric nanoparticles without a requirement for surfactants. The nanoparticles have a typical diameter of 75 nm. The nanoparticles may be used, for example, for drug delivery, including efficient and effective drug delivery against cancers such as triple negative breast cancers.

There is described an acrylic polyester resin, obtainable by grafting an acrylic polymer with a polyester material. The polyester material is obtainable by polymerizing (i) a polyacid component, with (ii) a polyol component. At least one of the polyacid component and/or the polyol component comprises a monomer having an aliphatic group containing at least 15 carbon atoms. At least one of the polyacid component and/or the polyol component comprises a functional monomer operable to impart functionality on to the polyester resin, such that an acrylic polymer may be grafted with the polyester material via the use of said functionality. Also provided is an aqueous coating composition comprising the acrylic polyester resin and a packaging coated with the composition.

By incorporating a polyoxyalkylene-modified organo(poly)siloxane compound having a specific structure as an emulsifier or emulsification aid, an organopolysiloxane having a high degree of polymerization can be easily emulsified. The obtained organpolysiloxane emulsion composition has excellent resistance to polar solvents including DMF and is dispersible in water. When incorporated into a resin composition of either the solvent-based type including an organic solvent or the water-based type, the emulsion composition can hence impart slipperiness, wear resistance, and glossiness without causing cissing or blushing.

By incorporating a polyoxyalkylene-modified organo(poly)siloxane compound having a specific structure as an emulsifier or emulsification aid, an organopolysiloxane having a high degree of polymerization can be easily emulsified. The obtained organpolysiloxane emulsion composition has excellent resistance to polar solvents including DMF and is dispersible in water. When incorporated into a resin composition of either the solvent-based type including an organic solvent or the water-based type, the emulsion composition can hence impart slipperiness, wear resistance, and glossiness without causing cissing or blushing.

The present invention relates, in one aspect, to a thermosetting resin composition including an epoxy resin, an isocyanate resin, a polyrotaxane resin, and a curing agent, wherein the isocyanate resin includes a hexamethylene skeleton and at least one selected from a biuret skeleton, an isocyanurate skeleton, an allophanate skeleton, a neopentyl skeleton, a butylene skeleton, and a dicarboxyl skeleton in a structure thereof.

To provide a polyacetal resin composition and a molded article thereof, which are less likely to crack even if stressed in contact with any hydrochloric acid-containing liquid. The polyacetal resin composition contains, per 100 parts by mass of a polyacetal resin: 0.01 to 10 parts by mass of at least one fatty acid metal salt selected from 1) to 3) below; and 0.1 to 5 parts by mass of a stress relaxant having a melting point of 67.5° C. to 200° C. when measured by using a differential scanning calorimeter at a flow rate of nitrogen of 20 cm.sup.3/min and at a heating rate of 10° C./min. 1) metal salt formed of long chain fatty acid having 10 to 34 carbon atoms and calcium; 2) metal salt formed of long chain fatty acid having 10 to 34 carbon atoms and zinc; and, 3) metal salt formed of long chain fatty acid having 10 to 34 carbon atoms and magnesium

The present invention is broadly concerned with novel directed self-assembly compositions, processes utilizing those compositions, and the resulting structures that are formed. The composition comprises a block copolymer of polystyrene and a polymethylmethacrylate block with polylactic acid side chains (“PS-b-P(MMA-LA)”). The block copolymer is capable of crosslinking and micro-phase separating into lines and spaces measuring about 10-nm or smaller with sub-20 nm L.sub.0 capability. Additionally, PS-b-P(MMA-LA) can be thermally annealed without a top-coat for simpler processing than the prior art. The polylactic acid side chains also increase the etch rate of the poly(methylmethacrylate) block when exposed to oxygen plasma, as well as lower the T.sub.g.