In accordance with some aspects, the present disclosure is directed to medical compositions that comprises (a) a first hydrophilic polymer functionalized with a plurality of first functional groups and (b) a second hydrophilic polymer functionalized with a plurality of second functional groups, wherein the first and second functional groups are selected to react and form covalent bonds upon a change in conditions such that the first and second hydrophilic polymers crosslink with one another. In other aspects the present disclosure is directed to kits that comprise such medical compositions and to medical procedures that utilize such medical compositions.

In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

The present invention relates to an antibacterial co-polymer comprising a water soluble backbone polymer having in at least one end a dendritic or hyperbranched polymer of generation 1 to 6 wherein at least one functional group comprising a carboxylic amine has been covalently attached to the periphery of the dendritic or hyperbranched polymer. The present invention also relates to said anti-bacterial co-polymer when said co-polymer has been cross-linked with a cross-linking agent and to uses of the cross-linked co-polymer in a hydrogel for the treatment or prevention of bacterial infections, particularly in surgical site infections (SSIs).

The present invention relates to a hyperbranched polyether of formula (I) R.sub.mQ.sub.n-0-R.sup.1 (I), wherein Q is a branching unit of formula, n is 2.sup.k1, m is 2.sup.k, k is 2, 3, 4, 5 or 6, each R is independently a hydrocarbon radical having at least 10 carbon atoms, R.sup.1 is a polymer having a number average molecular weight M.sub.n of at least 250 g/mol, wherein each branching unit Q is connected via ether linkage to adjacent branching units Q and each terminal oxygen of Q, not connected to adjacent branching units Q, is connected to R via ether linkage, as well as mixtures thereof. The present invention further relates to formulations comprising said hyperbranched polyether or mixture of ethers as well as their use.

##STR00001##

It is an object of the present invention to provide a resin composition for FRP, an FRP sheet and a molded product that enable inhibition of the whitening in and between fiber bundles. A resin composition for FRP according to an embodiment of the present invention is a resin composition with which a fibrous reinforcement sheet is to be impregnated for formation of FRP, and contains methyl methacrylate as a principal component, a methyl methacrylate polymer, a polymerization initiator, and at least one of dendrimer (meth)acrylate and glycidyl (meth)acrylate, as a monomer. An FRP sheet according to another embodiment of the present invention includes a matrix and a fibrous reinforcement sheet in the matrix. The matrix contains the hardened resin composition for FRP.

Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.

The present invention provides a polycarbonate composition and a molded article prepared therefrom. The polycarbonate composition provided by the present invention comprises (50-90) wt. % of polycarbonate, (5-45) wt. % of mineral filler and (1.5-4.5) wt. % of hydroxyl-terminated 5 dendritic branched polyester. The polycarbonate composition and the molded article provided according to the present invention have enhanced impact strength, increased tensile elongation at break, improved flowability and good surface gloss.

The present invention provides a polycarbonate composition and a molded article prepared therefrom. The polycarbonate composition provided by the present invention comprises (50-90) wt. % of polycarbonate, (5-45) wt. % of mineral filler and (1.5-4.5) wt. % of hydroxyl-terminated 5 dendritic branched polyester. The polycarbonate composition and the molded article provided according to the present invention have enhanced impact strength, increased tensile elongation at break, improved flowability and good surface gloss.

There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.