A fluorescent resin composition including a urethane resin which is a polymer having at least a polyol compound (A), a polyisocyanate compound (B) and a chain-extending compound (C) as structural units, and a fluorescent dye that emits fluorescence by undergoing irradiation with near infrared light within a wavelength region of 700 nm to 1300 nm, the polyol compound (A) being an aliphatic polycarbonate diol (A1). In addition, a molded object made of the above-described fluorescent resin composition, and also a medical device including the molded object. Examples of the medical device can include a wire for detecting the position of a lymph vessel that includes the molded object made of the fluorescent resin composition as a fluorescent marker.

The present invention relates to a new multicomponent plastic product comprising at least two different thermoplastic materials, wherein a first thermoplastic material comprises a first thermoplastic polymer, and a second thermoplastic material comprises a second thermoplastic polymer and a drug. According to the invention, the second thermoplastic material has a transformation temperature strictly lower than the transformation temperature of the first thermoplastic material and wherein the first and second plastic materials are at least partially adjacent in the multicomponent product.

An orthopaedic brace includes two rigid valves hinge-coupled to one another and each having a respective pelvic section and a respective supporting shell. The pelvic sections are rigidly coupled to the supporting shells of the respective valves and are made of a thermoformable polymeric material having a softening point between 45° C. and 80° C.

Provided are compositions (which may inks), methods, devices, and systems that are used with 3D printing. The compositions contain fluoropolymer particles, one or more type of a medium, one or more surfactants, and one or more shear thinning agents. The fluoropolymer component can be one or more of polytetrafluoroethylene (PTFE), perfluoroalkoxy, fluorinated ethylene-propylene, and poly ethyl enetetrafluoroethylene. Cartridges that contain the compositions are also provided. Methods of making the compositions, methods of using the compositions for 3D printing, and articles of manufacture, such as medical devices, are also provided.

A cationic contact lens is described as well as methods of manufacturing the same. The cationic contact lens includes a polymeric lens body that is the reaction product of a polymerizable composition that includes at least one siloxane, at least one nonionic hydrophilic monomer and at least one acyclic tertiary amine monomer. The cationic contact lens can be an unworn sterile silicone hydrogel contact lens. The contact lens is capable of substantially linear release of a releasable anionic agent and the at least one acyclic tertiary amine monomer facilitates uptake and/or sustained release of the releasable anionic agent by the polymeric lens body. The contact lens can be present in a sealed contact lens package. The sealed contact lens package can include at least a) a base member having a cavity; b) a contact lens packaging solution in the cavity; c) a unworn sterile contact lens immersed in the contact lens packaging solution in the cavity with the releasable anionic agent present; and d) a cover that forms a liquid-tight seal with the base member.

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

Provided is a polymer-based antimicrobial composition that is non-toxic, water soluble, and that mitigates the transmission of infectious diseases from surfaces. The composition comprises a cationic polymer, at least one adhesion promoter, optionally organic and/or inorganic particles that are photocatalytically active in visible light, and a carrier, in which the components of the composition are not covalently bound to one another. Also provided is an antimicrobial composition that comprises at least (i) a polyethylenimine-based polymer and a carrier or (ii) an organic and/or inorganic particle that is photocatalytically active in visible light, an adhesion promoter, and a carrier. The antimicrobial compositions can be applied to disinfect a surface and to form residual self-sanitizing films on the surface that are removable.

The present invention provides a biomedical electrode composition capable of forming a living body contact layer for a biomedical electrode that is excellent in conductivity and biocompatibility, is light-weight, can be manufactured at low cost, and can control significant reduction in conductivity even though the biomedical electrode is soaked in water or dried. The present invention was accomplished by a biomedical electrode composition including a polymer compound having both the ionic repeating unit “a” and the repeating unit “b” of (meth)acrylate, in which the ionic repeating unit “a” is a repeating unit of sodium salt, potassium salt, or ammonium salt including a partial structure represented by the following general formula (1), and the repeating unit “b” of (meth)acrylate is a repeating unit represented by the following general formula (2). ##STR00001##

Disclosed in the present invention is a method for preparing a Y-branched hydrophilic polymer carboxylic acid derivative, in particular a method for preparing a Y-branched polyethylene glycol carboxylic acid derivative having a high purity and high molecular weight. The preparation steps are simple, the product of the reaction is easy to be separated, the cost for separation is low, and the purity and yield of the product are high, facilitating the subsequent preparation of other derivatives and medicament conjugates based on the preparation of the carboxylic acid derivative, which is advantageous for industrial scale-up and commercial applications. The prepared Y-branched hydrophilic polymer carboxylic acid derivative (in particular the Y-branched polyethylene glycol carboxylic acid derivative having a high molecular weight) product has a high purity and high commercial application value, in particular in the use of the preparation of medicaments for preventing and/or treating diseases.

The disclosure relates to a composition of biocomposite based on natural rubber containing sol-bioglass, which is used and intended for insulating layers and pads in flexible antennas which can be worn in close vicinity with regard to the human body without adversely affecting it. According to the invention, the composition of the biocomposite intended and designed for insulating layers and pads in flexible antennas based on natural rubber is filled with sol-gel derived bioglass amounting to a quantitative range starting from 8 to 50 parts by weight with regard to 100 parts by weight rubber and having following list of remaining ingredients: zinc oxide from 2.5 to 3.5, stearic acid from 1 to 2.5, bis (triethoxysilylpropyl) tetrasulfide from 4 to 6, tertiary butyl-benzothiazolyl sulfenamide from 1 to 2.5, sulfur from 1 to 3 and isopropyl-phenyl-β-phenylene diamine from 0.5 to 1.5.