A medical rubber composition can contain, comprise, consist, or consist essentially of: (a) an isobutylene-isoprene rubber: (b) a diene-based rubber; and a silica having a BET specific surface area not lower than 130 m.sup.2/g. An amount of (a) the isobutylene-isoprene rubber contained in 100 parts by mass of a rubber component composed of (a) the isobutylene-isoprene rubber and (b) the diene-based rubber can be larger than 30 parts by mass and smaller than 55 parts by mass.

A process of stabilizing the activity of an enzyme against inactivation by water weathering are provided including associating one or more polymeric moieties of a polyoxyethylene having a molecular weight of 10,000 Daltons or greater with an enzyme to form a chemically modified enzyme; and dispersing said chemically modified enzyme in a base to form a water-stabilized active coating material.

Described herein are wound dressing comprising a silicone hydrogel composition and optionally an antimicrobial agent, and methods of making and use thereof. The silicone hydrogel compositions comprise an actinically-crosslinkable polysiloxane-polyglycerol block copolymer crosslinked with a crosslinker. The actinically-crosslinkable polysiloxane-polyglycerol block copolymer being derived from: a polysiloxane prepolymer comprising a polyglycerol side chain, the polyglycerol side chain comprising an ethylenically unsaturated group covalently linked thereto, wherein the ethylenically unsaturated group is actinically curable.

The invention relates to a composition comprising: (A) a propylene-based polymer which is a propylene homopolymer or a propylene copolymer consisting of at least 90 wt % of propylene monomer units and at most 10 wt % of ethylene monomer units and/or an α-olefin monomer units having 4 to 10 carbon atoms, (B) an elastomer of ethylene and an α-olefin comonomer having 4 to 10 carbon atoms, wherein the elastomer has a density of 0.850 to 0.865 g/cm 3 and a melt flow index of 0.1 to 20 dg/min measured in accordance with ASTM D1238 using a 2.16 kg weight and at a temperature of 190° C. and (C) a block copolymer comprising a terminal block comprising styrene or alpha-methylstyrene.

Provided is a bioink comprising a mixture comprising a collagen and a polysaccharide, and a polyhedral oligomeric silsesquioxane (POSS), a hydrogel matrix formed from a bioink comprising a mixture comprising a collagen and a polysaccharide, and a polyhedral oligomeric silsesquioxane (POSS), a 3D biomaterial scaffold comprising a hydrogel matrix of the disclosure as a first hydrogel layer and a hydrogel matrix of the disclosure as a second hydrogel layer, optionally having an intervening layer between the first hydrogel layer and the second hydrogel layer, and methods of forming and using same.

Bioactive coatings suitable for facilitating removal of a fingerprint when contacting the coating are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate. Also provided are processes of facilitating fingerprint removal.

Disclosed herein are polyesteramide random copolymers having high glass transition temperatures, methods of forming such polymers, devices, formulations, and medical devices containing such polymers, and methods of treating mammals suffering from various conditions using such polymers in combination with a bioactive agent. In an embodiment, the random copolymers may have a Tg above body temperature, about 37° C., and may achieve a longer release duration, different release kinetics, improved barrier properties, or other benefits over polymers with Tg below 37° C.

The present invention relates to a method for preparing a chitosan succinate having excellent solubility and biocompatibility, and to a succinylated chitosan prepared thereby. The method for preparing a chitosan succinate according to the present invention can prepare a chitosan-based bio-substance having excellent hydrophilicity, cell proliferation rate, cell affinity, and cell proliferation performance through a simple process, thereby having excellent usability in vivo.

Disclosed herein in is a medical tube comprising a hydrogenated styrenic block copolymer having a formula A-B-A, (A-B-A).sub.nX or (A-B).sub.nX is disclosed, where n is an integer from 2 to 30, and X is residue of a coupling agent. Prior to hydrogenation, each A block is a monoalkenyl arene homopolymer block having a true peak molecular weight of 5 kg/mol to 15 kg/mol. Each B block is a controlled distribution copolymer block having a true peak molecular weight of 30 kg/mol to 200 kg/mol. The hydrogenated styrenic block copolymer has a midblock poly(monoalkenyl arene) content of 35 wt. % to 50 wt. % based on the total weight of the midblock, and physical properties that makes it useful for producing medical tubes having kink resistance.

A new class of silicone monomers, providing transparent materials and imparting hydrophilic properties have been developed. These materials are incorporated into ophthalmic devices such as soft and rigid gas permeable (RGP) contact lenses. These new silicone monomers include Polyhedral Oligomeric Silsesquioxane (POSS) with two polymerizable groups and six organofunctional groups. These types of structures incorporate at least two available sites for polymerization allowing for the incorporation of the silsesquioxane cage into the backbone of a macromolecule. Additional functional sites allow the design of specific chemical features which address needed material properties.