Described are contact lenses containing light absorbing chromophores, wherein the light absorbing chromophore is concentrated in one or more select regions of the lens. Also described are methods for making such contact lenses.

Described are contact lenses containing light absorbing chromophores, wherein the light absorbing chromophore is concentrated in one or more select regions of the lens. Also described are methods for making such contact lenses.

The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.

The disclosure provides for provides for water-soluble near-infra red (NIR) emissive compounds, processes of making the compounds thereof, and use of the compounds therein.

Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

The invention relates to a method for counting cells, such as bacteria and/or somatic cells in liquid samples, such as in dairy products, preferably raw milk. Disclosed is a method comprising a combination of steps that apply dimeric nucleic acid dyes that normally do not penetrate cells (=cell-impermeant dyes), which are rendered cell-permeant by using the right combination of pH, buffer and temperature.

The invention relates to a method for counting cells, such as bacteria and/or somatic cells in liquid samples, such as in dairy products, preferably raw milk. Disclosed is a method comprising a combination of steps that apply dimeric nucleic acid dyes that normally do not penetrate cells (=cell-impermeant dyes), which are rendered cell-permeant by using the right combination of pH, buffer and temperature.

The invention provides fluorescent probes having the general formula (I)

##STR00001##

wherein X, Y, L and R.sup.1 to R.sup.4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

The present invention relates to a compound of the following formula (I): ##STR00001## The invention also relates to uses thereof as dye or pigment, notably as a luster pigment. The invention relates also to a reflective or photonic or nanophotonic or optoelectronic device comprising a compound of the invention. The invention relates also to a metal-like reflective coating, a metal-like particle or an organic-based metal-like liquid film comprising a compound of the invention.

Disclosed are photoactivable fluorescent dye compounds of formula I:

##STR00001##

wherein: n=0, 1, 2, 3; X is selected from O, CRR′, SiRR′ and GeRR′, where R and R′ represent independently alkyl, cycloalkyl, alkenyl, alkynyl or aryl; Y is H, SO.sub.3H or SO.sub.3M, with M being a positively charged counterion, in particular selected from NH.sub.4.sup.+ and cations of organic ammonium compounds; R.sup.1 is H, CO.sub.2H, C(O)NH-linker-CO.sub.2H, C(O)O-ligand, C(O)NH-ligand or C(O)NH-linker-ligand; R.sup.2 may represent H, unsubstituted or substituted alkyl (including cycloalkyl); R.sup.3 and R.sup.4 may represent independently H or F; R.sup.5 is H, Me, CO.sub.2H, C(O)NH-linker-CO.sub.2H, C(O)O-ligand, C(O)NH-ligand or C(O)NH-linker-ligand; wherein the ligand moiety at each occurrence represents a reactive group or tag, capable to form a covalent or non-covalent bond or molecular complex with a target chemical entity or substance. Methods of using the compounds in imaging of fixed and living cells are also disclosed.