The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

Provided is a cyanine compound being bound counterions consisting of an anion and a cation, wherein the anion is represented by the following formula (I-1):

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wherein R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a monovalent organic group; R.sup.3 and R.sup.4 each independently represent a monovalent group such as a phenyl group; X represents a hydrogen atom, a halogen atom or a monovalent organic group; and Y represents a divalent group such as a n-propenyl group.

A near-infrared absorbing composition includes: an organic dye; and a metal compound. The organic dye includes: at least one of a squarylium dye (A) or a cyanine dye (B) each having an absorption maximum in a range of 680 to 740 nm; and a cyanine dye (C) having an absorption maximum at 760 nm or higher. The metal compound includes at least a phosphonic acid and a copper ion, or a copper phosphonate complex formed from a phosphonic acid and a copper ion.

An optical member for use in a display device having a specific light emitting unit, which includes a specific light bending part and a light absorbing part having an absorption waveform selected from specific absorption waveforms A to D and having absorption waveform B: a specific absorption waveform in which two wavelengths that give an absorbance of half of an absorption maximum are present in a wavelength range larger than λ.sub.BMax (a maximum emission wavelength exhibited by blue emission of the display device) and smaller than λ.sub.GMax (a maximum emission wavelength exhibited by green emission of the display device) or C: a specific absorption waveform in which two wavelengths that give an absorbance of half of an absorption maximum are present in a wavelength range larger than λ.sub.GMax and smaller than λ.sub.RMax (a maximum emission wavelength exhibited by red emission of the display device).

The present invention relates to a compound represented by general formula (I) (in the formula (I), X represents a methyl group or a halogen atom; R.sup.1 to R.sup.14 each independently represent a hydrogen atom, a halogen atom, a cyano group, an optionally substituted alkyl group having 1 to 8 carbon atoms, or an optionally substituted aromatic hydrocarbon group having 6 to 12 carbon atoms; B.sup.m− represents a polyoxometalate anion; m represents an integer of 1 to 20; n represents an integer of 1 to 20, provided that n is determined such that the charge of the whole formula (I) becomes zero).

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Provided are any one of the following compounds and a fluorescently labeled biological substance having this compound.

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R.sup.1 to R.sup.27, L.sup.11, L.sup.12, and X.sup.+ represent a specific group, and at least one of R.sup.1 to R.sup.4 represents a substituted alkyl group.

In a case where at least one of R.sup.1 to R.sup.4 is an alkyl group having a carboxy group or a substituent capable of being bonded to a biological substance, at least one of R.sup.11 to R.sup.27 is an alkyl group or an aryl group, or at least one of R.sup.1 to R.sup.4, which does not correspond to the alkyl group having a carboxy group or an alkyl group having a substituent capable of being bonded to a biological substance, is an alkyl group having a sulfoalkyl group through a single bond or a linking group.

The total of n1 to n4 is an integer of 3 or more, and m=n1+n2+n3+n4−1 is satisfied.

At least one of R.sup.1 to R.sup.4, R.sup.13, L.sup.11 or L.sup.12 in Formula (1) and at least one of R.sup.1 to R.sup.4, R.sup.24, L.sup.11, or L.sup.12 in Formula (2) have a specific substituent.

The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.

A composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23° C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.