The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.

A laser markable article includes a first laser markable layer capable of forming a colour upon exposure to UV radiation, a second and optionally a third laser markable layer capable of forming a colour upon exposure to IR radiation, wherein the second or third laser markable layer includes a specific polymethine infrared radiation absorbing dye (IR dye). A colour laser marking method includes forming a first colour upon exposure to UV radiation and a second and optionally a third colour upon exposure to IR radiation.

The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

Provided are any one of the following fluorescent compounds and a fluorescent labeled biological substance having this fluorescent compound. ##STR00001## X represents CR.sup.5 or N, and R.sup.1 to R.sup.7, Q.sup.1, Q.sup.2, L.sup.1, and L.sup.2 each represent a specific group. a ring ?.sub.1 and a ring ?.sub.2 are a 5- to 8-membered ring, At least one of R.sup.1 to R.sup.7, L.sup.1, L.sup.2, Q.sup.1, or Q.sup.2 has a specific hydrophilic group. However, in a case where the ring ?.sub.1 and the ring ?.sub.2 are a 6-membered ring, and L.sup.1 and L.sup.2 are an arylene group, R.sup.5 is not an aryl group substituted with a linear alkyl group having 18 or more carbon atoms. In addition to the regulation of the ring ?.sub.1, the ring ?.sub.2, L.sup.1, and L.sup.2, in a case where R.sup.5 has a substituent having a dipyrromethene boron complex structure, the dipyrromethene boron complex structure has a structure in which a dipyrromethene skeleton is coordinately bonded to a boron atom in the tridentate or tetradentate coordination.

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient ##STR00001##

A colored composition of the present invention includes a dye compound having an anionic moiety including at least one of a structure represented by the following General Formula (A1), a structure represented by the following General Formula (A2), and a structure containing a boron atom, and a dye structure having a cationic moiety, in which the anionic moiety and the cationic moiety are bonded to each other via a covalent bond and present in the same molecule; a curable compound; and a solvent.

##STR00001## (in General Formula (A1), R.sup.1 and R.sup.2 each independently represent SO.sub.2 or CO)

##STR00002## (in General Formula (A2), R.sup.3 represents SO.sub.2 or CO; and R.sup.4 and R.sup.5 each independently represent SO.sub.2, CO, or CN)

The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.