The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and * acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.

A near infrared absorbing dye includes a croconium-based compound shown in formula (AI). In formula (AI), ring Z is either an optionally substituted 6-membered ring including no heteroatom or an optionally substituted 5-membered ring including 0 to 3 heteroatoms in the ring, R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, and R.sup.1 and a carbon atom or heteroatom as a part of ring Z may be linked to each other to respectively form a heteroring A, a heteroring B, and a heteroring C together with a nitrogen atom.

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The present disclosure provides SWIR-active small molecule polymethine dyes with improved properties for use in optical imaging, photothermal therapy, photodynamic therapy, and SWIR-promoted drug delivery.

The present invention is directed, in certain embodiments, to polymerizable near-IR dyes and polymers comprising said dyes as monomeric residues. In other embodiments, the present invention also relates to methods for the preparation of polymerizable near-IR dyes, and to the use of polymerizable near-IR dyes in the preparation of fluorescent polymers.

This current disclosure is directed to charge-transfer heptamethine dyes for NIR singlet oxygen generation, each such dye comprising a near-infrared (NIR) absorbing dye having heptamethine linkages orthogonally coupled to an optionally substituted cationic heteroaryl ring moiety as a charge-transfer partner and uses thereof.

Provided are a curable composition, a cured film, an optical filter, a solid image pickup element, an image display device, an infrared sensor, a dispersing auxiliary agent, a dispersion, and a method of manufacturing a dispersion. With the curable composition, a cured film having excellent moisture resistance in which the formation of an aggregate derived from a compound having a colorant skeleton is suppressed can be formed. This curable composition includes: a compound A having a structure in which at least one functional group selected from an acid group having a pKa of 3 or lower and a Clog P value of 1.1 or higher, an anionic group obtained by dissociating one or more hydrogen atoms from the acid group, or a salt of the acid group is bonded to a -conjugated structure of a colorant skeleton and having a maximum absorption wavelength in a wavelength range of 650 to 1200 nm; a curable compound; and a solvent.

An embodiment of the present invention is to provide a resin composition including a near infrared absorbing coloring agent represented by Formula (1) and a resin, a resin molded article, and a method of producing a resin molded article. In Formula (1), a ring A and a ring B each independently represent an aromatic ring or a heteroaromatic ring, X.sup.A and X.sup.B each independently represent a monovalent substituent, G.sup.A and G.sup.B each independently represent a monovalent substituent, kA represents an integer of 0 to n.sub.A, kB represents an integer of 0 to n.sub.B, n.sub.A represents the largest integer of G.sup.A which may be substituted in the ring A, n.sub.B represents the largest integer of G.sup.B which may be substituted in the ring B, X.sup.A and G.sup.A, and X.sup.B and G.sup.B may be respectively bonded to one another to form a ring, and in a case where a plurality of G.sup.A's and G.sup.B's are present, the plurality of G.sup.A's and the plurality of G.sup.B's may be respectively bonded to one another to form a ring structure.

##STR00001##

Disclosed are a fluorescent dye, a preparation method and an application thereof. The fluorescent dye has a structure of formula (I), where X and Y are independently selected from O, S, C(CH.sub.3).sub.2 and NR.sub.6; R.sub.2 and R.sub.3 are independently hydrogen or a functional group: R.sub.1, R.sub.4, R.sub.5 and R.sub.6 are independently selected from functional groups; and Z.sup. is a negative ion. The fluorescent dye has an ability to permeate the living cell membrane, so that it can be used in the fluorescence imaging of living cell microstructures, and can also be used in the STED super-resolution fluorescence imaging and laser scanning confocal microscopy of live cells.

A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.