The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method for synthesizing a compound of the formula: ##STR00001##

The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient ##STR00001##

Described herein are compositions relating to cell-penetrating conjugates of formula (I) or (IV). The compositions are capable of penetrating cells and recognizing intracellular targets (e.g., STAT3) and are, inter alia, useful for diagnostic and therapeutic purposes.

A colored composition of the present invention includes a dye compound having an anionic moiety including at least one of a structure represented by the following General Formula (A1), a structure represented by the following General Formula (A2), and a structure containing a boron atom, and a dye structure having a cationic moiety, in which the anionic moiety and the cationic moiety are bonded to each other via a covalent bond and present in the same molecule; a curable compound; and a solvent.

##STR00001## (in General Formula (A1), R.sup.1 and R.sup.2 each independently represent SO.sub.2 or CO)

##STR00002## (in General Formula (A2), R.sup.3 represents SO.sub.2 or CO; and R.sup.4 and R.sup.5 each independently represent SO.sub.2, CO, or CN)

A composition includes: a coloring material that allows transmission of infrared light and shields visible light; an infrared absorber; and a resin, in which the infrared absorber includes a compound having an absorption maximum in a wavelength range of longer than 900 nm and 1000 nm or shorter, and a ratio A/B of a minimum value A of an absorbance of the composition in a wavelength range of 400 to 950 nm to a maximum value B of an absorbance of the composition in a wavelength range of 1100 to 1300 nm is 4.5 or higher.

A color developing composition which develops colors in a high density and does not significantly discolor when aged, a lithographic printing plate precursor which has excellent plate-inspecting properties by means of color development and is capable of maintaining strong color development even when aged after color development, a plate making method for a lithographic printing plate in which the lithographic printing plate precursor is used, and a new compound that can be preferably used as a color developer. The color developing composition of the present invention includes a compound represented by Formula 1. The compound in the present invention is represented by Formula 1. In Formula 1, R.sup.1 represents a group in which an R.sup.1O bond is cleaved by heat or exposure to infrared rays. ##STR00001##

Near infrared and shortwave infrared dyes can have polymethine structures.

The present disclosure provides a compound of Formula (I), (II), or (III):

##STR00001##

an ionic derivative thereof, an isomer thereof, or a salt thereof. The present disclosure also provides conjugates of the compounds, and methods of using the compounds and the conjugates. The disclosure also provides the use of the compounds and conjugates in methods of sequencing nucleic acids.

Luminescent reporter compounds that are rotaxanes having the structure

##STR00001##

where BZC is a reporter molecule based on a squaraine type molecule, or similar reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.