The present invention is a crystal of 3-(3-{[3-(cyclomaltoheptaos-21-O-yl)propyl]amino}-3-oxopropyl)-2-{(1E)-2-[(3E)-3-{(2E)-2-[3-(3-{[3-(cyclomaltoheptaos-21-O-yl)propyl]amino}-3-oxopropyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene]ethylidene}-2-methoxycyclohex-1-en-1-yl]ethen-1-yl}-1,1-dimethyl-1H-benzo[e]indol-3-ium chloride.

Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

Described herein are compositions relating to cell-penetrating conjugates of formula (I) or (IV). The compositions are capable of penetrating cells and recognizing intracellular targets (e.g., STAT3) and are, inter alia, useful for diagnostic and therapeutic purposes.

A compound of Formula (1) and a labeled biological substance having the compound. ##STR00001## Z.sup.1 and Z.sup.2 represent a specific 6-membered ring, and at least one of Z.sup.1 or Z.sup.2 is a benzene ring having a specific substituent at an ortho position with respect to a nitrogen atom to which L.sup.1 or L.sup.2 is bonded, or a specific nitrogen-containing 6-membered ring in which a ring-constituting atom located at the ortho position is a nitrogen atom. The compound has at least one structure represented by (CH.sub.2CH.sub.2O).sub.mR.sup.21 on a heterocyclic ring, and has at least one substituent capable of being bonded to a carboxy group or a biological substance at a specific position, and in a case where at least one of Z.sup.1 or Z.sup.2 is the specific nitrogen-containing 6-membered ring, the specific substituents may be bonded to each other to form a ring.

The disclosure relates to a benzopyrylium dye of the formula (I),

##STR00001##

in which R.sup.200, R.sup.201, R.sup.202, R.sup.203, R.sup.204, R.sup.205, R.sup.206, R.sup.207 and R.sup.208 independently of one another are each hydrogen, C.sub.1 to C.sub.16 alkyl, C.sub.4 to C.sub.7 cycloalkyl, C.sub.7 to C.sub.16 aralkyl, C.sub.6 to C.sub.10 (het)aryl, hydroxyl, C.sub.1 to C.sub.6 alkoxy, or dialkylamino, the dialkylamino being selected from the group consisting of diethylamino, dimethylamino, diisopropylamino, a six-membered saturated ring attached via the N of the amino group, which may additionally contain an N or O and may be substituted by nonionic arbitrary radicals, or a combination of at least two thereof, and/or R.sup.200 with R.sup.201 or R.sup.201 with R.sup.202 or R.sup.202 with R.sup.203 and/or R.sup.205 with R.sup.206 and/or R.sup.206 with R.sup.207 each independently of one another form a CHCHCHCH bridge, and A is a CH.sub.2 or a CH.sub.2CH.sub.2 bridge, where the anion An.sup.n has a molecular weight of 200 g/mol and does not contain a halogen atom.

The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.