The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

The present invention relates to an optical filter containing: an absorption layer containing a near-infrared absorbing dye satisfying the following (i-1) to (i-5), and a transparent resin; and a reflection layer, and satisfying the following (ii-1); (i-1) .sub.max(A) TR is in a wavelength range of 760 to 900 nm; (i-2) T.sub.435-480ave (A) TR and T.sub.480-590ave (A) TR are both 90% or more. (i-3) .sub.max(A) DCM is in a wavelength range of 760 to 900 nm. (i-4) T.sub.435-480ave (A) DCM is 95% or more and T.sub.480-590ave (A) DCM is 97% or more. (i-5) a difference between T.sub.435-480ave (A) DCM and T.sub.435-480ave (A) TR, and a difference between T.sub.480-590ave (A) DCM and T.sub.480-590ave (A) TR are 10.5% or less. (ii-1) an average transmittance of light in the wavelength range of 800 to 900 nm is 5% or less at an incident angle of 60 degrees.

Provided are a protective sheet and a spectacle lens including at least one dye selected from the group consisting of a dye represented by Formula (1) and a dye represented by Formula (2), and application thereof. In Formula (1), R.sup.71 to R.sup.74 each independently represent a hydrogen atom, an alkyl group, an alkoxy group, or the like. In Formula (2), R.sup.21 represents an alkyl group, an aryl group, a heterocyclic group, or the like, R.sup.22 represents a hydrogen atom, a halogen atom, an alkyl group, or the like, and at least one of R.sup.21 or R.sup.22 is an alkyl group having 4 or more carbon atoms. n represents 0 or 1, and m represents an integer of 1 to 5. ##STR00001##

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Encrypted markers that are not readily detectable can be revealed by treatment with a specific reagent used as a developer to reveal a readily detectable physical property of the marker, such as a characteristic fluorescence emission after excitation with a particular excitation wavelength, or to reveal a visible color. The encrypted marker can be developed in situ, or a sample can be removed by brushing, scraping, swabbing or scratching the marked object or item and developing the encrypted marker or a sample thereof with the appropriate developer to reveal an overt marker or optical signal. The encrypted marker may include a DNA taggant.

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

Fluorescent chromophores nicknamed BOPHY are provided. The chromophores may be readily synthesized in two steps from readily available reagents via the coupling of a pyrrole aldehyde or ketone with hydrazine, followed by reaction with BF.sub.3. The resultant symmetric and dimeric tetracycle is comprised of two BF.sub.2 units in six-member chelate rings, appended by pyrrole units on the periphery. The quantum yield of fluorescence for the unmodified compound and the tetramethyl variant are near unity, with values 95 and 92% respectively in CH.sub.2Cl.sub.2.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

A near infrared absorbing dye includes a croconium-based compound shown in formula (AI). In formula (AI), ring Z is either an optionally substituted 6-membered ring including no heteroatom or an optionally substituted 5-membered ring including 0 to 3 heteroatoms in the ring, R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, and R.sup.1 and a carbon atom or heteroatom as a part of ring Z may be linked to each other to respectively form a heteroring A, a heteroring B, and a heteroring C together with a nitrogen atom.

##STR00001##

In a thermal transfer recording sheet including a base material and a colorant layer, the colorant layer includes a yellow dye layer containing a yellow dye, a magenta dye layer containing a magenta dye, and a cyan dye layer containing a cyan dye, and the cyan dye includes a compound represented by Formula (1a) or Formula (1b): ##STR00001##
where R.sub.1 to R.sub.7 are substituents, X.sup. is an anion, and the compound of Formula (1b) has at least one anionic substituent.