A method and composition of an organic manufactured photochromic dye that is free of carcinogens, non-mutagenic, non-toxic to human skin in any concentration, and suitable for application to, and absorbable by, human skin. The photochromic dye is suitable to be applied directly to human skin, and which dye is configured to indicate exposure to UV rays. The composition is configured to change color upon exposure to UVA, UVB and/or UVC rays. The composition can be used with other compositions, such as sunscreen, and be applied to human skin prior to application of the sunscreen, or, formulated with the sunscreen such that when the active ingredients of the sunscreen diminish, the photochromic dye will change color to generate a visual indicator of this condition.

The present invention relates to a novel crystal form, manufacturing procedures, pharmaceutical compositions, formulations and medicaments comprising a N-methylisoindigo crystalline, methods of preparation, and the use of the N-methylisoindigo crystalline to prepare a medicament to prevent cancer, or treat cancer or an inflammatory-related disease associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines.

A method and composition of a photo chromic dye suitable to be applied directly to human skin, and which dye is configured to indicate exposure to UV rays. The composition is configured to change color upon exposure to UVA, UVB and/or UVC rays. The composition can be used with other compositions, such as sunscreen, and be applied to human skin prior to application of the sunscreen, or, formulated with the sunscreen such that when the active ingredients of the sunscreen diminish, the photo chromic dye will change color to generate a visual indicator of this condition.

A method and composition of a photo chromic dye suitable to be applied directly to human skin, and which dye is configured to indicate exposure to UV rays. The composition is configured to change color upon exposure to UVA, UVB and/or UVC rays. The composition can be used with other compositions, such as sunscreen, and be applied to human skin prior to application of the sunscreen, or, formulated with the sunscreen such that when the active ingredients of the sunscreen diminish, the photo chromic dye will change color to generate a visual indicator of this condition.

Functionalized fluorescent tracers, compositions, and methods for extracting the functionalized fluorescent tracers from oil phases and other wellbore or drilling fluids are provided. In some implementations, a sorbent for extracting tracer molecules from a fluid includes a silica-based sorbent. The silica-based sorbent includes a hydrophobic functional group and an ionic functional group. In some implementations, the ionic functional group is positively charged. In some implementations, the ionic functional group is negatively charged. A method of extracting a functionalized dye from an oil phase includes mixing a sorbent for extracting tracer molecules with an oil phase sample that includes a functionalized fluorescent tracer, recovering the sorbent from the oil phase, and dispersing the sorbent in an organic solvent. In some implementations, the method includes lowering the pH of the organic solvent. In some implementations, the method includes raising the pH of the organic solvent.

The aqueous ink includes a pigment, a resin dispersant and an aqueous medium. The pigment contains C.I. Pigment Orange 43. The aqueous ink has an absorbance ratio of 0.95 or more to 1.15 or less, which is represented by the following equation (1). An absorbance of 50% by mass of an upper layer when the aqueous ink is centrifuged at 217,000 G for 30 minutes at a pigment content of 1.5% by mass is less than 0.20 in a wavelength range of 350 nm or more to 550 nm or less.

[00001]$\begin{array}{cc}\mathrm{Absorbance}\mathrm{ratio}=\mathrm{absorbance}\mathrm{at}\mathrm{peak}\mathrm{around}\mathrm{wavelength}\mathrm{of}532\mathrm{nm}/\mathrm{absorbance}\mathrm{at}\mathrm{peak}\mathrm{around}\mathrm{wavelength}\mathrm{of}496\mathrm{nm}& \left(1\right)\end{array}$

A reactive disperse yellow dye is suitable for supercritical CO.sub.2 anhydrous dyeing. The reactive disperse yellow dye in has a parent of azo structure, and has monochlorometriazinyl groups thereon. The reactive disperse yellow dye can be used for supercritical CO.sub.2 anhydrous dyeing of cellulose fiber, protein fiber, chemical fiber and the blended fabrics thereof, and has good dyeing effect particularly for cotton-polyester blended products.

Provided are fluorescent nanoparticles and their conjugates and methods of using the same for in vivo and in vitro diagnostics and other applications. In some embodiments, provided are fluorescent nanoparticles with high solid-state absolute quantum yield. In some embodiments, provided are methods of manufacturing such nanoparticles. Nanoparticles may comprise monomers, such as styrene, and fluorophores, such as AlEgen Bright Green.

A method for preparing high-purity gardenia yellow pigment includes: taking gardenia fruit, performing degreasing and impurity removal treatment on gardenia dry powder, and preparing a crude extract of gardenia dry powder by supercritical fluid extraction combined with a pre-formulated pigment carrier. A pigment adsorption resin is then prepared, followed by wet column packing of the pigment adsorption resin. The crude pigment extract is loaded onto the column for adsorption, and the pigment is eluted using a 45% ethanol solution, separating the yellow pigment solution and impurity solution. By employing the degreasing and impurity removal treatment of gardenia dry powder, and using the pigment adsorption resin to purify the crude pigment extract, the invention achieves a high-purity and high-color-value gardenia yellow pigment, while also enabling the separation of gardenia glycoside and chlorogenic acid from the gardenia yellow pigment.