Provided are a composition of which dispersibility of particles including a pyrrolopyrrole coloring agent is satisfactory, a method of manufacturing a composition, a curable composition, a cured film using a curable composition, a near-infrared cut filter, a solid-state imaging device, an infrared sensor, and a camera module. The composition includes particles including a coloring agent represented by Formula (1), in which an average secondary particle diameter of the particles is 500 nm or less. R.sup.1a and R.sup.1b each independently represent an alkyl group, an aryl group, or a heteroaryl group, R.sup.2 and R.sup.3 each independently represent a hydrogen atom or a substituent, R.sup.2 and R.sup.3 may be bonded to each other to form a ring, R.sup.4's each independently represent a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, BR.sup.4AR.sup.4B, or a metal atom, R.sup.4's may form a covalent bond or a coordinate bond with at least one selected form R.sup.1a, R.sup.1b, or R.sup.3, and R.sup.4A and R.sup.4B each independently represent a hydrogen atom or a substituent.

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There are provided fluorogenic labelling agents comprising a dimaleimide core connected to a BODIPY-based fluorophore, processes for preparation thereof, and uses thereof for labelling and/or detection of specific protein targets. Fluorogenic labelling agents having an excitation wavelength that can be visualized in the green or red channels of fluorescence microscopes are provided. In some embodiments, fluorogenic labelling agents comprising a compound having the structure of Formula I or II, and salts thereof, are described.

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The invention provides a method for treating a microbial infection in an infected subject comprising administering to the subject an antimicrobial composition comprising a therapeutically effective amount of one or more lipophilic cation, and, optionally, another one or more antimicrobial compound or antimicrobial agent. The invention further provides a pharmaceutical composition with antimicrobial properties comprising a therapeutically effective amount of one or more lipophilic cation and another one or more antimicrobial compound or antimicrobial agent.

The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE.sup./) mice along with the endothelial cell age-delaying effects of Mito-Esc.

Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.

The disclosed hemicyanine dyes contain an amino-chromene moiety as an electron donor, facilitating a variety of optical properties and uses in sensing applications.