The present invention relates to an at least partly implantable system for injecting a substance into a patient's body. The system comprises at least one implantable infusion needle arranged in at least one first housing, the at least one implantable infusion needle having a tip end for injecting a substance into a penetration area of a patient, and at least one drive unit coupled to the at least one implantable infusion needle and arranged for moving the tip end of the at least one infusion needle for varying the penetration site, wherein the at least one drive unit is a drive unit arranged for moving the tip end of the at least one infusion needle using hydraulic force. The system is adapted to use infusion liquid to be injected into the patient's body as hydraulic fluid.

The invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, diagnostic compositions comprising the conjugates, their use, and their production.

Disclosed herein is a tricyclic octacationic cyclophane and complexes comprising the tricyclic octacationic cyclophane and a perylene diimide dye complexed therein and methods of using and making the cyclophane and complexes.

Disclosed herein are receptor-substrate complexes comprising an octacationic tricyclic cyclophane and a pyrrole dye complexed therein and methods of using and making the same.

Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.

An object of the present invention is to provide a luminescent ethylene-based copolymer which causes no problem of the shift or bleeding-out of a fluorescent body, which has a high workability, desired optical properties and a good light stability and which is easily handled in a kneading step; and a encapsulant composition for a solar cell, using this copolymer. Another object of the invention is to provide a encapsulant layer, for a solar cell, which is formed using the photovoltaic encapsulant composition to cause no problem of the shift or bleeding-out of a fluorescent body in this layer and to have desired optical properties and a good light stability; and a photoelectromotive module having this layer. The copolymer is a luminescent ethylene-based copolymer including, as a monomer component, a fluorescent dye compound having an unsaturated bond.

The present invention provides a fluorescent polymer comprising a fluorophore perylene bisimide (PBI) and oligo (p-phenylene vinylene) (OPV) functionalized with carboxy and amine functionality groups and a polystyrene (PS) backbone for the detection of volatile organic compound, a process for the detection and a kit thereof.

Described herein are polymeric chromophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric chromophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric chromophores and methods of preparing and using the same.

Embodiments of the present invention provides compounds, compositions, and methods for their preparation or synthesis that provide polymer-based cationic particles, such as, e.g., polymer-nucleic acid complexes, for delivering molecules including biomolecules, which is particularly desirable in gene therapy. Inventive materials include positively-charged linear homopolymers and block copolymers by living free radical polymerization, and polymer-based particles by emulsion polymerization. These polymers and particles may be conjugated with a wide range of biomolecules, and may deliver molecules, including, drug molecules, contrast agents, dyes, and the like, by loading them into the interior of the particles prior to polymerization. These conjugated and/or labeled polymers and particles may be delivered to cells to administer their cargo and achieve a therapeutic response. Additional embodiments may be directed to the methods of synthesizing and using the compounds and compositions, as well as kits comprising the compounds, compositions, and formulations, and desired molecules for delivery.

A method for the production of a sol-gel based matrix resulting in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes.