The present invention is about a pharmaceutical composition, an oral preparation, and an injection preparation containing a G protein-coupled Receptor19 (GPCR19) agonist, specifically sodium taurodeoxycholate(HY2191) and its derivative, as an active ingredient for preventing or treating allergic skin diseases. The present invention is also about an external preparation and a cosmetic composition containing said pharmaceutical composition for preventing and improving allergic skin diseases. The said pharmaceutical composition shows an excellent efficacy in treating and improving allergic dermatitis compared with the steroid ointments or immunosuppressive ointments currently used. The said pharmaceutical composition reduces the level of serum IgE, which is a major factor causing allergic dermatitis, increases TH1 cytokine alleviating allergic dermatitis and reduces TH2 cytokine that exacerbates allergic dermatitis. The said pharmaceutical composition also reduces infiltration of a mast cell, eosinophil, and neutrophil in dermis and ameliorates clinical symptoms such as erythema, hemorrhage, edema, excoriation, erosion, scaling and dryness. Thus, the said pharmaceutical composition can be used to prevent and treat allergic skin diseases.

The present invention discloses a method of preparing a bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap, wherein the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap comprises the following components based on percentage by weight: Component A: Zanthoxylum schinifolium seed oil 15.0-21.0%, propylene glycol 12.0-17.0%, glycerin 6.0-11.0%, Component B: deionized water 5.0-8.0%, sodium alkyl ether sulfate AES 8.0-12.0%, Component C: lauric acid 5.0-8.0%, stearic acid 11.0-16.0%, Component D: 98% NaOH 2.5-4.5%, deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.3-0.8%. The skin care soap of the present invention is pale yellow and translucent, has good stability, provides great aroma and rich foam, and can nourish the skin and sterilize effectively.

The present invention discloses a method of preparing a bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap, wherein the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap comprises the following components based on percentage by weight: Component A: Zanthoxylum schinifolium seed oil 15.0-21.0%, propylene glycol 12.0-17.0%, glycerin 6.0-11.0%, Component B: deionized water 5.0-8.0%, sodium alkyl ether sulfate AES 8.0-12.0%, Component C: lauric acid 5.0-8.0%, stearic acid 11.0-16.0%, Component D: 98% NaOH 2.5-4.5%, deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.3-0.8%. The skin care soap of the present invention is pale yellow and translucent, has good stability, provides great aroma and rich foam, and can nourish the skin and sterilize effectively.

The use of (i) water, (ii) sugar, sorbitol or a mixture thereof and (iii) humectant is used for improving heat transfer to a soap.

The use of (i) water, (ii) sugar, sorbitol or a mixture thereof and (iii) humectant is used for improving heat transfer to a soap.

A process comprising at least the steps of: (a) preparing a first mixture comprising at least one non-polar organic solvent, at least one first polar organic solvent and a catalyst, (b) preparing a second mixture comprising at least one of: C7 to C25 carboxylic acids, optionally alkyl benzene sulfonic acids and C2 to C6 carboxylic acids, (c) adding an amount of a calcium base to the first mixture to obtain a third mixture, (d) adding the second mixture of acids of step (b) to the third mixture of step (c) to obtain a fourth mixture; and carbonating the fourth mixture of step (d) by adding therein a given amount of an organic carbonate, wherein in step (c), the added amount of the calcium base allows neutralization of the carboxylic acids in step (d) and forms water as a neutralization product. The process is free of carbon dioxide injection for carbonation.

A process comprising at least the steps of: (a) preparing a first mixture comprising at least one non-polar organic solvent, at least one first polar organic solvent and a catalyst, (b) preparing a second mixture comprising at least one of: C7 to C25 carboxylic acids, optionally alkyl benzene sulfonic acids and C2 to C6 carboxylic acids, (c) adding an amount of a calcium base to the first mixture to obtain a third mixture, (d) adding the second mixture of acids of step (b) to the third mixture of step (c) to obtain a fourth mixture; and carbonating the fourth mixture of step (d) by adding therein a given amount of an organic carbonate, wherein in step (c), the added amount of the calcium base allows neutralization of the carboxylic acids in step (d) and forms water as a neutralization product. The process is free of carbon dioxide injection for carbonation.

A cleaning bar is provided, comprising: a cleaning surfactant; water; and a crosslinked cellulose ether containing 0.1 to 0.6 wt %, based on weight of the crosslinked cellulose ether, of polyether groups; wherein the cleaning bar is a solid.

The present invention relates to an extruded soap bar composition. It more particularly relates to a soap bar composition which comprises specified type of sodium alumino silicate gel to produce soap bars with high water content that are not only easy to extrude but have the desired hardness.

The present invention relates to an extruded soap bar composition. It more particularly relates to a soap bar composition which comprises specified type of sodium alumino silicate gel to produce soap bars with high water content that are not only easy to extrude but have the desired hardness.