Embodiments described herein relate to an apparatus for positioning and securing an excised biological tissue specimen for imaging and analysis. In some embodiments, an apparatus includes a sample bag defining an inner volume configured to receive a biological tissue sample, and a sealing member coupled to the sample bag. An imaging window is disposed and configured to be placed in contact with at least a portion of the biological tissue sample, and a positioning member is coupled to the imaging window and is configured to be disposed against the sealing member to substantially seal the inner volume. The positioning member includes a vacuum port disposed and configured to be aligned with a vacuum source to withdraw air from the inner volume of the sample bag.

A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

A method for operating a bioreactor includes passing a drive shaft into a first tubular connector and a second tubular connector projecting from the first tubular connector, the first tubular connector and the second tubular connector being at least partially disposed within a container, the first tubular connector being more flexible than the second tubular connector, the second tubular connector having a length that comprises at least 20% of a combined length of the first tubular connector and the second tubular connector. Rotating the drive shaft so as to rotate the first tubular connector and the second tubular connector within the container.

A bioreactor includes a flexible container and an impeller assembly having a hollow tube. The impeller assembly is coupled to the flexible container. At least one mixing element is removably disposed on the hollow tube. A drive shaft is adapted to engage the hollow tube of the impeller assembly and facilitate rotational movement of the hollow tube.

Provided is a liquid feeding device which can improve collection efficiency of fine particles on an individual particle basis while improvement of workability is realized.

A liquid feeding device includes: an introduction portion disposed on one end portion of the liquid feeding device, and configured to introduce a liquid into a closed space; a discharge portion disposed on another end portion of the liquid feeding device, and configured to discharge the liquid supplied into the closed space; and an upper wall provided so as to oppose the upper surface of the chip, and configured to define the closed space. The upper wall has an inclined surface which is provided such that a gap formed between the inclined surface and the chip is reduced from an introduction portion side toward a discharge portion side.

The invention relates to a method for monitoring the temperature of a cryopreserved biological sample. The invention also relates to a device for monitoring the temperature of a cryopreserved biological sample. The device (10) for monitoring the temperature of a cryopreserved biological sample comprises a sample container (1) having a receiving space (2) for receiving a biological sample (6). The device also comprises at least one chamber (11) having an interior that is not fluidically connected to the receiving space (2) and is only partially filled with an indicator substance (7) with a melting temperature in a region of 20 C. to 140 C. The chamber (11) has a barrier (13) that causes the indicator substance (7) to move into a second sub-region (12b) of the chamber (11) when the indicator substance (7) in a first sub-region (12a) of the chamber is in the fluid aggregate state.

The invention relates to a device for monitoring the temperature of a cryogenically preserved biological sample. The device (10) comprises a sample container (1) having a receptacle space (2) for accommodating a biological sample (6). The device further comprises at least one chamber (11), the interior (12) of which is not fluidically connected to the receptacle space, and which is at least partially filled with an indicator substance (7) having a boiling point or sublimation temperature in a range from 10 C. to 140 C. The chamber (11) further has at least one opening via which the indicator substance (7) can escape from the interior (12) of the chamber (11) upon exceeding its boiling point or sublimation point. The invention further relates to a method for monitoring the temperature of a cryogenically preserved biological sample.

Embodiments described herein relate to an apparatus for positioning and securing an excised biological tissue specimen for imaging and analysis. In some embodiments, an apparatus includes a sample bag defining an inner volume configured to receive a biological tissue sample, and a sealing member coupled to the sample bag. An imaging window is disposed and configured to be placed in contact with at least a portion of the biological tissue sample, and a positioning member is coupled to the imaging window and is configured to be disposed against the sealing member to substantially seal the inner volume. The positioning member includes a vacuum port disposed and configured to be aligned with a vacuum source to withdraw air from the inner volume of the sample bag.

The present invention provides a cell culture vessel and a jig for fixing the cell culture vessel in position. More specifically, the cell culture vessel of the present invention is provided with a vessel portion having an annular sealed culture space when viewed from overhead and a port portion connecting the inner portion and outer portion of the culture space. The vessel portion is provided with a first vessel wall serving as the upper side during culturing and a second vessel wall serving as the lower side during culturing. Preferably at least the first vessel wall has flexibility.

The present invention describes a device used to process a sample and detect the presence or absence of certain molecules in the sample. The device includes a pouch having two or more compartments that may be created by sealing two or more films. In a preferred embodiment, the pouch is made by a single sheet of film that has been folded onto itself. In another preferred embodiment, the pouch is made by sealing two films. In other aspects, this invention describes methods to process a sample.