An apparatus for managing gas bubbles in a bioprocessing system includes a body portion having a underside surface, and an opening in the body portion. The body portion is configured for placement within a bioreactor vessel such that the underside surface of the body portion is disposed in a liquid within the bioreactor vessel. The underside surface of the body portion is configured to divert rising gas bubbles in the liquid towards the opening.

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a first sparger connected to the collapsible bag, and a second sparger connected to the collapsible bag.

A computer implemented method for detecting foam on the surface of a liquid medium contained in a vessel is described. The method including the steps of receiving a sample image of at least a portion of the vessel comprising the liquid-gas interface and classifying the sample image between a first class and at least one second class, associated with different amounts of foam on the surface of the liquid. The classifying is performed by a deep neural network classifier that has been trained using a plurality of training images of at least a portion of a vessel comprising a liquid-gas interface. The plurality of training images may comprise at least some images that differ from each other by one or more of: the location of the liquid-gas interface on the image, the polar and/or azimuthal angle at which the liquid-gas interface is viewed on the image, and the light intensity or colour temperature of the one or more light sources that illuminated the imaged portion of the vessel when the image was acquired. Related methods for controlling a bioprocess, for providing a tool, and related systems and computer software products are also described.

The present disclosure provides methods and systems for foam control. A method of foam control for a fermentation system comprises: obtaining image data from an imaging device located at the fermentation system; and processing said sensor data using a trained machine learning algorithm to generate an output that indicates presence of foam or level of foaming.

A fermentation reactor is shown with a loop-part and a top tank, the loop-part having a downflow part, connected to an upflow part via a U-part, wherein the top tank includes: (i) a first outlet connecting the top tank to the downflow part of the loop-part and allowing a fermentation liquid present in the top tank to flow from the top tank into the loop-part; (ii) a first inlet connecting the top tank to the upflow part of the loop-part, allowing fermentation liquid present in the loop-part to flow from the loop part into the top tank; and (iii) a vent tube for discharging effluent gasses from the top tank; wherein the top tank further includes a visual inspection means.

A system to reduce surface bubbles from cell culture media using ultrasonic pulses is disclosed. The system includes a plurality of ultrasonic transducers, a photodetector, a camera, a control circuit, and a cell culture container that includes a cell culture media. The control circuit is communicatively coupled to the plurality of ultrasonic transducers, the temperature sensor, and the camera. The photodetector is used to determine a presence of a surface bubble on the cell culture media. The camera is used to determine a location of the surface bubble when the presence of the surface bubble is determined. The plurality of ultrasonic transducers is used to position an ultrasonic pulse at the location of the surface bubble and thereby reduce the presence of the surface bubble on the cell culture media when the location of the surface bubble is determined.

A vessel configured to contain a liquid is provided. The vessel includes a collapsible bad, a reusable support structure, a sensor, and a controller. The collapsible bag is operative to contain the liquid. The reusable support structure is operative to support the collapsible bag. The sensor is operative to measure a parameter within the collapsible bag. The controller is in electronic communication with the sensor and operative to introduce an antifoaming agent into the collapsible bag based at least in part on a signal received from the sensor.

A vessel configured to contain a liquid is provided. The vessel includes a collapsible bad, a reusable support structure, a sensor, and a controller. The collapsible bag is operative to contain the liquid. The reusable support structure is operative to support the collapsible bag. The sensor is operative to measure a parameter within the collapsible bag. The controller is in electronic communication with the sensor and operative to introduce an antifoaming agent into the collapsible bag based at least in part on a signal received from the sensor.

A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.

Black powder flowing with hydrocarbons in a hydrocarbon pipeline is converted into a magnetorheological slurry by implementing wet scrubbing in the hydrocarbon pipeline. A flow of the magnetorheological slurry through the hydrocarbon pipeline is controlled.