A cell culture cartridge is provided comprising a plurality of zones geometrically configured to provide for symmetrical fluid flow with each of the plurality of zones to avoid dead areas in flow within each of the plurality of zones. In certain embodiments, at least eight inlets are provided, with an inlet positioned at each corner of the cell culture cartridge. In certain embodiments, a shared outlet is positioned on a top surface of the cell culture cartridge.

There is provided a bioreactor including: a chamber unit having an accommodating space therein; an upper fixing member and a lower fixing member that are disposed at respective planes perpendicular to a central axis of the chamber unit inside the chamber unit and are movable in a central-axis direction of the chamber unit; and a filling layer that is formed in a space between the upper fixing member and the lower fixing member inside the chamber unit and contains a plurality of carriers.

The present invention relates to smart tank for a bio-pharma process line, a smart tank assembly, a method for assembling a smart tank and a system comprising multiple smart tanks. The smart tank comprises a top plate element, at least one sidewall element, and a bottom plate element, wherein the top plate element, the at least one sidewall element and the bottom plate element are arranged to form a reservoir for receiving at least one biochemical medium. The smart tank comprises further at least one channel, for guiding the at least one biochemical medium and/or an operating medium. The at least one channel extends within the top plate element and at least one of the at least one sidewall element and/or the bottom plate element.

A method for preparing a solid medium platform for cultivating algae, comprising obtaining an algae culture solution (“ACS”) at approximately room temperature of a specific volumetric quantity, denoted “x”; creating raw agarose solution (“AS”) by adding low melting point agarose powder (“AP”) to water of a volume equal to “x” in a container that is different from the one used for said ACS; heating and stirring AS; cooling or waiting for the AS to cool down to approximately 15-35% above the gelling temperature of the AS; adding micronutrients supportive of algae growth after AS has cooled to approximately 15-35% above the gelling temperature of the AS to create an agarose micronutrient solution (“AMS”); after the AMS has cooled, combining the AMS with ACS and pouring the mixture into an open container and stirring; apportioning the AMS/ACS mixture into cultivating container(s); and waiting for the mixture to congeal.

Disclosed is a biomanufacturing apparatus (1) comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40/240) for supporting a bioreactor, a tray support (45/245) including a mechanism (44,47/244,247) for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.

The present invention features filtration assemblies, cassettes, systems, and methods for filtering cells from a sample solution and then incubating the captured cells.

The present application belongs to the technical field of biology. Provided is a photobioreactor used for algae cultivation, said photobioreactor comprising: a reactor main body, a separation unit, and a first aeration device. The reactor main body is a sealed irregular tubular shape, the separation unit is located within the reactor main body, and divides the reactor main body into two spaces, a left space and a right space, and the first aeration device is connected to a bottom portion of the reactor main body. Also provided is an algae cultivation system, comprising the photobioreactor, the second aeration device, and a temperature control system, and being capable of regulating the temperature of an algae solution.

A culture device and a culture method by which a substance to be cultured can be three-dimensionally cultured, and the substance thus cultured can be removed as an integrated product with multiple tubes; and a cultured organ produced by the culture method. The culture device comprises a sealed container (2) which contains the substance to be cultured (A) and is disassembled after the culture is completed; multiple ducts (3, 4, 5) arranged in the sealed container (2) and having a plurality of micropores formed on the outer peripheral surface; a culture medium-feeding device (6, 7) for feeding/circulating the culture medium (B) to at least one duct (3 or 5); an excretory device (8) connected to at least one duct (4) for excreting the waste product (C)permeating into the duct (4) through the micropores of the duct (4) from the substance to be cultured to the outside of the sealed container.

Mesofluidic devices for culturing cell aggregates and methods of using the same are disclosed. An exemplary mesofluidic device comprises at least one fluid inlet, at least one fluid outlet, a plurality of fluid channels, and a plurality of culture chambers. Each culture chamber can comprise at least one chamber inlet and at least one chamber outlet. The at least one chamber inlet can be in fluid communication with the at least one fluid inlet via at least one of the plurality of fluid channels. The at least one chamber outlet can be in fluid communication with the at least one fluid outlet via at least one of the plurality of fluid channels. The mesofluidic device can be configured to contain a cell aggregate in each of the plurality of culture chambers.

Settling devices for separating particles from a bulk fluid with applications in numerous fields. The particle settling devices include a first stack of cones with a small opening oriented upwardly or downwardly. Optionally, the settling devices may include a second stack of cones with a small opening oriented downwardly or upwardly. The cones may be concave or convex. These devices are useful for separating small (millimeter or micron sized) particles from a bulk fluid with applications in numerous fields, such as biological (microbial, mammalian, plant, insect or algal) cell cultures, solid catalyst particle separation from a liquid or gas and waste water treatment.