An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.

A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

A well plate cover includes a base defining a base plane, and a plurality of insertion elements. At least a portion of each of the insertion elements is transparent. Each of the insertion elements is coupled to the base, and extends, in a direction orthogonal to the base plane, from the base to a distal end surface of the insertion element. The distal end surface of each of the insertion elements includes an apex that, when the respective insertion element is inserted into a well of a well plate, extends further into the well than any other portion of the distal end surface. The apex is a point, a line, or a plane having a diameter that is less than one half of a maximum diameter of the distal end surface.

The cell evaluation device includes a cell housing unit 111, and an adapter 120 configured to be elastically deformed by being fitted into the cell housing unit to close a top opening of the cell housing unit, and the adapter includes a body 121 to be inserted into the cell housing unit, a positioning unit 122 configured to position the body in a vertical direction with respect to the cell housing unit, a culture medium inlet port 124 and a culture medium outlet port 125 penetrating the top end and the lower end of the body, and a flexible sheet member 123 which is provided on a lower end of the body and extends radially outward from an outer edge of the lower end. This makes it possible to prevent leakage of the culture medium in the cell evaluation device.

An apparatus for minimizing dead leg spaces in a container or tubing includes a first member having a flange for attaching the first member to a wall of the container or tubing, the flange having at least one aperture, and a second member rotatably coupled to the first member, the second member having an upper end having at least one aperture, and an open distal end. The second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid.

Some fluid coupling devices described herein are configured for use in fluid systems. For example, some embodiments described in this document are single-use, aseptic fluid coupling devices that can be coupled to create a sterile flow path therethrough. Some such aseptic couplings are genderless couplings such that two identical aseptic couplings can be coupled together and then latched to form a robust connection between the aseptic couplings.

A system and method for creating mycelium textile materials is disclosed, in which leftover, cutoff, and other materials used to create the textile materials that would otherwise be discarded are further used in a second process to create bonded mycelium boards. The system and method further reuse or recycle materials throughout the process of creating the mycelium textile fabric and bonded mycelium boards, thus keeping waste to a minimum.

A disposable polymer container for manipulation of small specimens adapted to optimize heat transfer between an external heating element and specimens herein contained. In particular, this invention relates to the field of containers for Assisted Reproductive Technology hereunder In-vitro fertilization (IVF).

A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

A pressure buffering system includes a housing, a pump module, a pressure sensor and a pressure cylinder. The pump module, the pressure sensor and the pressure cylinder are disposed in the housing. The pressure cylinder is communicated between the pump module and the pressure sensor. A biological culture device is further provided.