A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

The present disclosure describes automated systems and methods for handling objects, such as culture plates or dishes. For example, in one embodiment, the present disclosure describes an automated stacker and de-stacker comprising a clamping mechanism, a lift pad, a pair of pins, and a cabinet. A stack of culture plates may be stored in the cabinet. During a stacking operation, the pair of pins may be raised to stop a culture plate traveling along a conveyor track. Once stopped, the culture plate may be raised above the conveyor track by the lift pad and clamped by the clamping mechanism. During a de-stacking operation, the clamping mechanism may be opened, and the culture plate may be lowered onto the conveyor track by the lift pad.

A heating assembly for a bioreactor is disclosed. The heating assembly includes a holder having a plurality of segments coupled to each other to define a unitary structure and a heating component coupled to at least one segment of the plurality of segments. The unitary structure includes a top end, a bottom end, and a side wall. The side wall extends between the top end and the bottom end and along a circumferential direction of the heating assembly to define a cavity. At least a portion of the unitary structure has a gradually varied perimeter along a direction perpendicular to a plane which intersects the side wall and is parallel to the top end and the bottom end.

A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.

Systems and methods for conducting surface-mediated chemical and/or biochemical reactions within an enclosed chamber are disclosed. Systems and methods of the present disclosure may be used in conducting hybridization reactions of biopolymers. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the direction of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing and the direction of mixing at least once over the course of a reaction.

A cell culture apparatus includes: a cylindrical member that includes a body cylindrical portion and a culture membrane arranged at an opening end portion of the body cylindrical portion; and a cylindrical covering member that is fitted to the body cylindrical portion and includes (i) a first cylindrical portion which covers an outer circumferential surface of the body cylindrical portion when fitted to the cylindrical member and (ii) a second cylindrical portion which is adjacent to the first cylindrical portion in an axial direction of the covering member and forms a container with the culture membrane serving as a bottom surface when fitted to the cylindrical member, and the first cylindrical portion includes a first part in which a length in the axial direction is a first length and a second part in which the length is a second length shorter than the first length.

The present invention relates to a CO2 incubator device and a cloud system connecting the CO2 incubator device with a cloud server. The device includes a plurality of removable incubation unit trays wherein each tray acts as a separate incubator and individual bioreactor. The device includes an inlet valve and an outlet valve for each tray for inflow and outflow of CO2 gas. A microprocessor is coupled to a microcontroller for controlling temperature and CO2 level in the trays based on excess CO2 level present in the trays. A cloud server is connected to the device using a communication protocol for enabling the microprocessor to transmit incubator data to the server and to modify the incubation conditions. The data is stored in a cloud database for enabling users to remotely access the incubator data. The multiple trays are accessed independently enabling multiple users to interact with the incubator.

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

A bench top incubator is described. The bench top incubator includes a first tray stack designed to retain microscope slides in a plurality of slide trays and a second tray stack designed to retain multi-well plates in a plurality of plate trays. The incubator is relatively simple and small in design and can be conveniently located to carry out temperature processing of biological samples such as fixed cells and tissues, biological fluids, and so forth.

Disclosed is a bioreactor including a rotation device that rotates a reaction container while a reference direction is taken as an axial direction thereof, and an angle adjusting device coupled to the rotation device to adjust an angle defined by the reference direction, which is dependent on an arrangement posture of the rotation device, with respect to a ground surface, by changing the arrangement posture of the rotation device.