A device arrangement for performing at least one unit operation in a biopharmaceutical process comprises a central operating module having a control means. The device arrangement further comprises a process plate which is provided for attachment to the operating module. On the process plate, process components which are essential for carrying out the unit operation can be pre-assembled.

A rover-based integrated laboratory system including autonomous mobile robots is disclosed. Namely, a rover-based integrated laboratory system is disclosed comprising a workspace; a laboratory component within the workspace, the laboratory component being adapted to perform a laboratory technique; a labware component within the workspace that is adapted to be used in the laboratory technique; and a rover component within the workspace that is operatively connected to the laboratory and the labware components, the rover component being an autonomous mobile robot.

A cell culture device includes an isolator and an incubator. A connection unit is used to connect the isolator and the incubator, and is provided with: a flexible cell supply tube extending from the incubator to the isolator; and a tube support unit having a holding part holding the cell supply tube and a connection end part attached to the incubator. The tube support unit can be switched between a first configuration in which the tube support unit supports the cell supply tube such that the cell supply tube extends in a first direction and a second configuration in which the tube support unit holds the cell supply tube such that the cell supply tube extends in a second direction. The second configuration is switched to the first configuration by means of the restoring force of the tube support unit.

Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.

A main isolator 2 (main aseptic device) includes a main connection part 6 having an opening O through which a work space W is externally opened, and an internal opening and closing member 22 configured to open and close an internal opening 21a of the main connection part 6 on the work space W side. A manual incubator 3 (first auxiliary aseptic device) includes a first auxiliary connection part 7 connectable with the main connection part 6 of the main isolator 2, and an automatic incubator 4 and a housing container 5 (second auxiliary aseptic devices) each include a second auxiliary connection part 8 smaller than the first auxiliary connection part 7. In addition, an external blockage member 9 configured to externally block the opening O of the main connection part 6 is provided.

The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for controlling a flow of fluid in a fluid line connected to said container; a pump device (8) for generating a conveyor pressure of the fluid in the fluid line; a control device (10) which can be connected to the valve (6) and/or the pump device (8) in order to control the valve (6) and/or pump device (8); and a frame (2) which supports said container receiving portion (4), valve (6), pump device (8) and control device (10).

A renewable energy microgeneration apparatus is disclosed that includes a mixing tank that mixes waste with a liquid, a buffer tank that receives and pre-warms the mixed waste, a pasteurization tank that pasteurizes on the pre-warmed mixed waste, a digestion tank that performs anaerobic digestion on the pasteurized waste, a de-watering device that separates liquid digestate and removes salt from the liquid, sensors that measure salinity and biogas quality, and a controller. The controller causes the transfer of digestate from the digestion tank to the pasteurization tank to the dewatering device, causes the de-watering device to separate the liquid and remove the salt from the liquid, monitors the salinity of the liquid and the quality of biogas using the sensors, and causes the mixing of the liquid with the waste and adjusts the feed rate of the waste to reduce the salinity of the waste and increase methane production.

Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.

Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses. A module comprising a valve, a filter or guard column, an affinity column, and a flow cell is provided with several ports for receiving tubing connections for a sample and one or more solvents, as well as one or more outlet ports for connections to one or more waste reservoirs. The flow cell may use UV light to determine a protein concentration of a sample in one particular example. The module can be connected directly or indirectly to a bioreactor containing the bioprocess and material to be sampled, and can be disposed of once a production run has been completed. In addition, manifolds are provided which can be embodied as a valve assembly, and which can comprise the same components and features as the disposable module. The manifolds and modules are compact and easy to use. A portable device for use with a module is also provided.