The present application relates to a bioreactor system for culturing cells, especially cells without cell walls; the bioreactor system includes: a container containing a hollow cylinder with a diameter of D1 and a height of H1, and a hollow circular truncated cone with an upper diameter of D2, a lower diameter of D3, and a height of H2, where the hollow cylinder is connected to a top surface of the hollow circular truncated cone, and D1=D2; an oscillator, configured to cause the container to make an eccentric motion according to a certain eccentricity and rotational speed; a ventilation device, configured to introduce an oxygen-containing gas from an upper portion of the container to the inside of the container, and a culture solution filled in the container, of which a top surface is exposed to the oxygen-containing gas; where the oscillator is configured to maintain the eccentric motion of the container, such that a ratio of the total liquid surface area to the volume (S/V) of the culture solution when in a steady state of motion is 5.65 or more, the turbulence kinetic energy is 2.73E−03 m.sup.2/s.sup.2 or more, and the flow field shear rate is 20.27/s or less, where the total liquid surface area is the sum of the contact area between the culture solution and the reactor wall surface and the contact area between the top surface and the gas.

Provided is a cell culture system capable of mixing a medium for culturing animal or plant cells. The cell culture system includes a body, a movable plate including an accommodation space accommodating a culture bag accommodating a medium to mix the medium, and being tiltable in multiple directions by a central joint mounted at a first location of the body, a first actuator mounted between the body and a second location of the movable plate to move the movable plate, a second actuator mounted between the body and a third location of the movable plate to move the movable plate, and a controller for applying a control signal to the first and second actuators, wherein a first angle between a first reference line extending from the first location to the second location, and a second reference line extending from the first location to the third location is 120°.

The present disclosure is directed to devices, systems and methods that include a stage and an actuator configured to transmit a orthogonal force to the stage, wherein the actuator is configured to receive a plurality of orthogonal acceleration signals, wherein the orthogonal acceleration signals comprise an actuator frequency signal and an actuator magnitude signal.

A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture (3; 103; 203) comprising said biomolecule to a magnetic separator (5; 105; 205) and providing to the magnetic separator magnetic beads comprising ligands capable of binding this biomolecule; —separating by the magnetic separator said magnetic beads with bound biomolecules from the rest of the feed; —forwarding said magnetic beads as a slurry with an added buffer to an elution cell (7; 107; 207); —eluting the bound biomolecules in the elution cell.

Provided is a high throughput photobioreactor. The high throughput photobioreactor includes: a chamber; a plate installed in the chamber and mounted with a plurality of wells; a plurality of light sources installed in the chamber and irradiating light toward the plate; a light quantity controller positioned on an upper part of the plate to make quantities of light irradiated to the plurality of wells different; and a temperature controller controlling a temperature of the plate.

A system that easily and stably separates various living cells of interest from a living body-derived tissue, the system including: a suspension unit that prepares a suspension by adding a proteolytic enzyme solution to a living body-derived tissue based on a parameter and shaking the tissue to which the solution has been added; a measurement unit that acquires information regarding the suspension; and an analysis unit that specifies a position of living cells from the information acquired by the measurement unit. Methods for separating various living cells of interest from a living body-derived tissue are also disclosed.

A probe assembly and a method of manufacturing a probe assembly. In one aspect there is a method of manufacturing a probe assembly comprising providing an electrode carrier carrying a plurality of electrodes, the electrode carrier comprising a top wherein the plurality of electrodes are exposed relative to the top and a bottom having a plurality of electrical contacts in electrical communication with the plurality of electrodes respectively; moulding a body around the electrode carrier to retain the electrode carrier whilst leaving the plurality of electrodes exposed. The invention also extends to a biomass monitoring system comprising a flexible enclosure including a probe assembly and support arrangement for receipt of the probe assembly in an engaged configuration.

A method, and also a gas supply system without a separate humidifying apparatus, for supplying gas to a plurality of bioreactors, divides a constant gas stream with high distribution accuracy into a plurality of gas substreams having a mandated volume flow, which can be kept constant at the mandated level even when during gas supply there is fluctuation in the opposing pressure in the gas line to the respective bioreactor, and decouples a gas distribution from the opposing pressure by hydrostatic pressure compensation, with the gas distribution at the same time producing an obligatory humidification of the gas stream.

A method for regulating parameters of at least two bioreactor bags individually, which bioreactor bags are provided on one and the same rocking part of a bioreactor system. The method includes the steps of: determining an individual weight of the content in each bioreactor bag at different points in time during processing; regulating one or more parameters in each bioreactor bag in dependence of the individual weights.

The present invention relates to. a bioreactor vessel (1) having an outer vessel wall (2) and a bottom (3), further comprising an integrated internal structure (4) providing at least two additional surfaces (4a), (4b) to the internal reactor space of said vessel, said internal structure (4) being spaced apart from said outer vessel wall (2), as well as to a process for growing biological cells using said bioreactor vessel.